Protection against salmonella typhimurium, salmonella gallinarum, and salmonella enteritidis infection in layer chickens conferred by a live attenuated salmonella typhimurium strain.
Protection against salmonella typhimurium, salmonella gallinarum, and salmonella enteritidis infection in layer chickens conferred by a live attenuated salmonella typhimurium strain.
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DOI：
10.4110/in.2015.15.1.27
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发表时间：
2015-02
期刊：
影响因子：
6
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Lee JH
在本研究中，我们研究了一种减毒肠沙门氏菌血清型鼠伤寒沙门氏菌（ST）对蛋鸡鼠伤寒沙门氏菌、鸡沙门菌（SG）和肠炎沙门菌（SE）感染的保护作用。禽在7日龄时口服ST减毒毒株，然后在初始免疫（PPI）后4周增强。连续监测血浆IgG和黏膜分泌IgA （sIgA）水平显示，接种ST诱导了针对ST、SE和SG抗原的显著抗体反应。此外，免疫组对3种沙门氏菌血清型有显著的淋巴增生性反应。我们还研究了对ST， SE和SG毒株攻击的保护。在毒力SG攻击后，免疫组的死亡率明显低于未免疫组。在免疫组的肝脏、脾脏和盲肠组织中，ST和SE强毒攻毒株的持久性降低，这表明用ST减毒株免疫不仅可以预防ST感染，还可以提供针对SE和SG感染的交叉保护。
In the present study, we investigated the protection conferred by a live attenuated Salmonella enterica serovar Typhimurium (ST) strain against Salmonella Typhimurium, Salmonella Gallinarum (SG), and Salmonella Enteritidis (SE) infection in layer chickens. Birds were orally primed with the attenuated ST strain at 7 days of age and then boosted at 4 weeks post prime immunization (PPI). Sequential monitoring of plasma IgG and mucosal secretory IgA (sIgA) levels revealed that inoculation with ST induced a significant antibody response to antigens against ST, SE, and SG. Moreover, significant lymphoproliferative responses to the 3 Salmonella serovars were observed in the immunized group. We also investigated protection against virulent ST, SE, and SG strain challenge. Upon virulent SG challenge, the immunized group showed significantly reduced mortality compared to the non-immunized group. The reduced persistence of the virulent ST and SE challenge strains in the liver, spleen, and cecal tissues of the immunized group suggests that immunization with the attenuated ST strain may not only protect against ST infection but can also confer cross protection against SE and SG infection.
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影响因子：
9.4
作者：
Alvarez, J;Sota, M;Garaizar, J
通讯作者：
Garaizar, J
影响因子：
2.8
作者：
Chaudhari, Atul A.;Lee, John Hwa
通讯作者：
Lee, John Hwa
DOI：
10.20506/rst.13.3.804
发表时间：
1994-09-01
期刊：
REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFICE INTERNATIONAL DES EPIZOOTIES
影响因子：
--
作者：
NASSAR, TJ;ALNAKHLI, HM;ALOGAILY, ZH
通讯作者：
ALOGAILY, ZH
影响因子：
5.5
作者：
Carvajal, Barbara Gonzalez;Methner, Ulrich;Berndt, Angela
通讯作者：
Berndt, Angela
影响因子：
3.1
作者：
El Ghany, Moataz Abd;Jansen, Angela;Dougan, Gordon
通讯作者：
Dougan, Gordon