Online evaluation of novel choices by simultaneous representation of multiple memories.

Online evaluation of novel choices by simultaneous representation of multiple memories.
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DOI:
10.1038/nn.3515
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发表时间:
2013-10
影响因子:
25
通讯作者:
Behrens, Timothy E. J.
Behrens, Timothy E. J.
中科院分区:
医学1区
文献类型:
--
作者:
Barron, Helen C.;Dolan, Raymond J.;Behrens, Timothy E. J.

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先前的经验在决策中起着至关重要的作用。它能够明确表示潜在的结果,并为评估机制提供培训。然而,我们也可以在没有先前经验的情况下做出选择,仅仅通过想象新经验的后果。在这里,我们使用功能磁共振成像重复抑制人类,我们展示了如何神经元表征的新奖励可以构建和评估。一个可能的新体验是通过调用海马体和内侧前额叶皮层内的多个独立记忆来构建的。这种构建只持续很短的时间,在此期间,在组成项目的记忆之间观察到新的联系。综上所述,这些发现表明,在没有直接经验的情况下,多个相关记忆的共同激活可以为评估系统提供一个训练信号,从而使新经验的后果能够被想象和采取行动。
Prior experience plays a critical role in decision making. It enables explicit representation of potential outcomes and provides training to valuation mechanisms. However, we can also make choices in the absence of prior experience, by merely imagining the consequences of a new experience. Here, using fMRI repetition suppression in humans, we show how neuronal representations of novel rewards can be constructed and evaluated. A likely novel experience is constructed by invoking multiple independent memories within hippocampus and medial prefrontal cortex. This construction persists for only a short time period, during which new associations are observed between the memories for component items. Together these findings suggest that in the absence of direct experience, co-activation of multiple relevant memories can provide a training signal to the valuation system which allows the consequences of new experiences to be imagined and acted upon.
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发表时间: 2007-12-26
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