Ranking lifestyle risk factors for cervical cancer among Black women: A case-control study from Johannesburg, South Africa.
Ranking lifestyle risk factors for cervical cancer among Black women: A case-control study from Johannesburg, South Africa.
复制标题
DOI：
10.1371/journal.pone.0260319
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Singh E
中科院分区：
文献类型：
--
作者：
Singini MG;Sitas F;Bradshaw D;Chen WC;Motlhale M;Kamiza AB;de Villiers CB;Lewis CM;Mathew CG;Waterboer T;Newton R;Muchengeti M;Singh E
Aside from human papillomavirus (HPV), the role of other risk factors in cervical cancer such as age, education, parity, sexual partners, smoking and human immunodeficiency virus (HIV) have been described but never ranked in order of priority. We evaluated the contribution of several known lifestyle co-risk factors for cervical cancer among black South African women. We used participant data from the Johannesburg Cancer Study, a case-control study of women recruited mainly at Charlotte Maxeke Johannesburg Academic Hospital between 1995 and 2016. A total of 3,450 women in the study had invasive cervical cancers, 95% of which were squamous cell carcinoma. Controls were 5,709 women with cancers unrelated to exposures of interest. Unconditional logistic regression models were used to calculate adjusted odds ratios (ORadj) and 95% confidence intervals (CI). We ranked these risk factors by their population attributable fractions (PAF), which take the local prevalence of exposure among the cases and risk into account. Cervical cancer in decreasing order of priority was associated with (1) being HIV positive (ORadj = 2.83, 95% CI = 2.53–3.14, PAF = 17.6%), (2) lower educational attainment (ORadj = 1.60, 95% CI = 1.44–1.77, PAF = 16.2%), (3) higher parity (3+ children vs 2–1 children (ORadj = 1.25, 95% CI = 1.07–1.46, PAF = 12.6%), (4) hormonal contraceptive use (ORadj = 1.48, 95% CI = 1.24–1.77, PAF = 8.9%), (5) heavy alcohol consumption (ORadj = 1.44, 95% CI = 1.15–1.81, PAF = 5.6%), (6) current smoking (ORadj = 1.64, 95% CI = 1.41–1.91, PAF = 5.1%), and (7) rural residence (ORadj = 1.60, 95% CI = 1.44–1.77, PAF = 4.4%). This rank order of risks could be used to target educational messaging and appropriate interventions for cervical cancer prevention in South African women.
登录
查看更多内容
影响因子：
5
作者：
BRINTON, LA;REEVES, WC;RAWLS, WE
通讯作者：
RAWLS, WE
影响因子：
34.3
作者：
Arbyn, Marc;Weiderpass, Elisabete;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
7.7
作者：
LICCIARDONE, JC;WILKINS, JR;CHANG, JC
通讯作者：
CHANG, JC
HPV辅助因子与宫颈癌的发展有关：哥斯达黎加的一项基于人群的研究结果。
影响因子：
8.8
作者：
Hildesheim A;Herrero R;Castle PE;Wacholder S;Bratti MC;Sherman ME;Lorincz AT;Burk RD;Morales J;Rodriguez AC;Helgesen K;Alfaro M;Hutchinson M;Balmaceda I;Greenberg M;Schiffman M
通讯作者：
Schiffman M
影响因子：
6.4
作者：
Lee, Chien-Hung;Lee, Jang-Min;Wu, Ming-Tsang
通讯作者：
Wu, Ming-Tsang