Effects of resveratrol on the levels of ATP, 5-HT and GAP-43 in the hippocampus of mice exposed to chronic unpredictable mild stress
Effects of resveratrol on the levels of ATP, 5-HT and GAP-43 in the hippocampus of mice exposed to chronic unpredictable mild stress
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白藜芦醇对慢性不可预测轻度应激小鼠海马ATP、5-HT和GAP-43水平的影响
DOI：
10.1016/j.neulet.2020.135232
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发表时间：
2020-07
影响因子：
2.5
通讯作者：
Er-Ping Xu
中科院分区：
文献类型：
--
作者：
Ji-Duo Shen;Yue-Wen Zhang;Bao-Ying Wang;Li Bai;Shuai-Fei Lu;Lei-Lei Zhu;Ming Bai;Yu-Cheng Li;Er-Ping Xu
Growing evidence suggested that energy deficiency might be involved in the pathophysiological mechanism of depression. Energy deficiency, mainly results from mitochondrial damage, can lead to the dysfunction of synaptic neurotransmission, and further cause depressive-like behavior. The antidepressant effect of resveratrol had been widely demonstrated in previous studies; however, the underlying mechanism remains poorly understood. The present study aimed to investigate whether the antidepressant effects of resveratrol involved in the energy levels and neurotransmission in the hippocampus. We found that resveratrol and fluoxetine significantly attenuated depressive-like behaviors induced by chronic unpredictable mild stress (CUMS), which evidenced by the increased sucrose preference and the reduced immobility time in a forced swimming test. In addition, resveratrol increased hippocampal ATP levels, decreased Na+-K+-ATPase and pyruvate levels, and upregulated the levels of mitochondrial DNA (mtDNA), mRNA expression of sirtuin (SIRT)1 and peroxisome proliferator-activated receptor γ coactivator (PGC)1α. Furthermore, resveratrol and fluoxetine increased serotonin (5-HT) levels and downregulated the mRNA expression of 5-HT transporter (SERT) in the hippocampus. The decreased protein expression of growth-associated protein (GAP)-43 induced by CUMS was also ameliorated by resveratrol and fluoxetine. These findings demonstrated the antidepressant effects of resveratrol and suggested that resveratrol was able to promote mitochondrial biogenesis, enhance ATP and 5-HT levels, as well as upregulate GAP-43 expression in the hippocampus.
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姜黄素可逆转慢性轻度压力引起的抑郁样行为和胰岛素抵抗
影响因子：
3.6
作者：
Shen Ji-Duo;Wei Yu;Li Yu-Jie;Qiao Jing-Yi;Li Yu-Cheng
通讯作者：
Li Yu-Cheng
白藜芦醇可以防止身体疲劳，并改善小鼠的运动表现。
DOI：
10.3390/molecules18044689
发表时间：
2013-04-19
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Wu RE;Huang WC;Liao CC;Chang YK;Kan NW;Huang CC
通讯作者：
Huang CC
影响因子：
4.8
作者：
Zhou Y;Wang S;Li Y;Yu S;Zhao Y
通讯作者：
Zhao Y
DOI：
10.1073/pnas.93.10.4760
发表时间：
1996-05-14
影响因子：
11.1
作者：
McMahon, HT;Bolshakov, VY;Sudhof, TC
通讯作者：
Sudhof, TC
影响因子：
--
作者：
L. Baxter;Jeffrey M. Schwartz;M. Phelps;J. Mazziotta;B. Guze;C. Selin;R. Gerner;R. Sumida
通讯作者：
L. Baxter;Jeffrey M. Schwartz;M. Phelps;J. Mazziotta;B. Guze;C. Selin;R. Gerner;R. Sumida