Chemistry, lung toxicity and mutagenicity of burn pit smoke-related particulate matter.
Chemistry, lung toxicity and mutagenicity of burn pit smoke-related particulate matter.
复制标题
化学，肺毒性和燃烧烟雾相关的颗粒物的诱变。
DOI：
10.1186/s12989-021-00435-w
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发表时间：
2021-12-16
影响因子：
10
通讯作者：
Gilmour MI
中科院分区：
文献类型：
--
作者：
Kim YH;Warren SH;Kooter I;Williams WC;George IJ;Vance SA;Hays MD;Higuchi MA;Gavett SH;DeMarini DM;Jaspers I;Gilmour MI
人为来源的开放燃烧可以释放危险的排放，并与心肺健康结局的患病率增加有关。
烟熏的烟雾是五个不同类型的燃烧坑的混合物：胶合板的混合物； -1小鼠和诱变活性沙门氏菌（AMES）诱变测定法使用有和没有代谢激活的基础固定菌株TA98和基本固定菌株TA100（来自大鼠肝脏的S9）。
烟气中发出的大多数颗粒和闷烧的混合物的直径小于2.5 µm，燃烧含有塑料的塑料（塑料，混合物或混合物/柴油），与其他类型的废物相比，与其他类型的废物相比，发出了更多的颗粒物（PM）。反应与升高的多环芳烃水平有关。
这项研究表明，燃烧烟雾暴露的不利影响因废物类型和混合温度而有所不同。
在线版本包含的补充材料可获得10.1186/s12989-021-00435-W。
Open burning of anthropogenic sources can release hazardous emissions and has been associated with increased prevalence of cardiopulmonary health outcomes. Exposure to smoke emitted from burn pits in military bases has been linked with respiratory illness among military and civilian personnel returning from war zones. Although the composition of the materials being burned is well studied, the resulting chemistry and potential toxicity of the emissions are not. Smoke emission condensates from either flaming or smoldering combustion of five different types of burn pit-related waste: cardboard; plywood; plastic; mixture; and mixture/diesel, were obtained from a laboratory-scale furnace coupled to a multistage cryotrap system. The primary emissions and smoke condensates were analyzed for a standardized suite of chemical species, and the condensates were studied for pulmonary toxicity in female CD-1 mice and mutagenic activity in Salmonella (Ames) mutagenicity assay using the frameshift strain TA98 and the base-substitution strain TA100 with and without metabolic activation (S9 from rat liver). Most of the particles in the smoke emitted from flaming and smoldering combustion were less than 2.5 µm in diameter. Burning of plastic containing wastes (plastic, mixture, or mixture/diesel) emitted larger amounts of particulate matter (PM) compared to other types of waste. On an equal mass basis, the smoke PM from flaming combustion of plastic containing wastes caused more inflammation and lung injury and was more mutagenic than other samples, and the biological responses were associated with elevated polycyclic aromatic hydrocarbon levels. This study suggests that adverse health effects of burn pit smoke exposure vary depending on waste type and combustion temperature; however, burning plastic at high temperature was the most significant contributor to the toxicity outcomes. These findings will provide a better understanding of the complex chemical and combustion temperature factors that determine toxicity of burn pit smoke and its potential health risks at military bases. The online version contains supplementary material available at 10.1186/s12989-021-00435-w.
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影响因子：
1.9
作者：
DEMARINI, DM;WILLIAMS, RW;LINAK, WP
通讯作者：
LINAK, WP
影响因子：
3.3
作者：
Foster, WM;Walters, DM;Miller, LM
通讯作者：
Miller, LM
影响因子：
2.8
作者：
DeMarini, David M.;Warren, Sarah H.;Gullett, Brian K.
通讯作者：
Gullett, Brian K.
影响因子：
7.4
作者：
de Souza, Carolina Vieira;Correa, Sergio Machado
通讯作者：
Correa, Sergio Machado
DOI：
10.1097/jom.0b013e31824fe154
发表时间：
2012-06-01
影响因子：
3.2
作者：
Conlin, Ava Marie S.;DeScisciolo, Connie;Smith, Tyler C.
通讯作者：
Smith, Tyler C.