Impacts of human papillomavirus vaccination for different populations: A modeling study.
Impacts of human papillomavirus vaccination for different populations: A modeling study.
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DOI：
10.1002/ijc.31409
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发表时间：
2018-09-01
影响因子：
6.4
通讯作者：
Franceschi S
中科院分区：
文献类型：
--
作者：
Baussano I;Lazzarato F;Ronco G;Franceschi S
HPV感染流行的国际差异源于性行为的差异，这也是不同人群中HPV感染的基本繁殖数(R0)的关键因素。R0影响牛群保护的强度，从而影响疫苗接种计划的影响。因此，类似的疫苗接种计划可能会产生不同程度的影响，这取决于接种前人群的HPV流行率。我们使用IARC的传播模型来评估(I)在15-34岁女性中接种疫苗与不接种疫苗的总体效果，以HPV16的患病率下降百分比(%PR)衡量，以及(Ii)在具有性别平等或传统性行为和不同性行为水平的人群中相应的羊群保护，对应于全球观察到的接种前HPV16流行率从1%到8%。在不同性别平等性行为水平的人群中，仅对女孩接种疫苗的百分比PR差异最大，为40%(接种前的流行率分别为91%和8%，PR分别为91%和48%)。HPV16的消除覆盖率分别为55%和97%。为了在接种后达到理想的HPV16流行率水平，在接种前HPV16流行率不同的人群中需要不同水平的覆盖率，例如，在性别均等的性行为人群中，将HPV16流行率从接种前的1%和8%降至1/1000将分别需要37%和96%的覆盖率。在传统人群中，相应的覆盖率分别需要达到28%和93%。总而言之，接种前的HPV流行率强烈影响群体免疫，并有助于预测HPV接种的整体效果。有什么新鲜事吗？不同人群的性行为差异导致了HPV感染率的十倍之多，而这反过来又会影响宫颈癌的风险。这些因素如何影响HPV疫苗接种计划的有效性？在这项流行病学研究中，作者发现，在性行为建立在传统规范基础上且HPV流行率仍然很低的国家，及早接种HPV疫苗将预见到由于社会态度的自由化，年轻女性中HPV流行率的增加。
International variations in the prevalence of HPV infection derive from differences in sexual behaviors, which are also a key factor of the basic reproductive number (R0) of HPV infection in different populations. R 0 affects the strength of herd protection and hence the impact of a vaccination program. Similar vaccination programs may therefore generate different levels of impact depending upon the population's pre‐vaccination HPV prevalence. We used IARC's transmission model to estimate (i) the overall effectiveness of vaccination versus no vaccination in women aged 15–34 years measured as percent prevalence reduction (%PR) of HPV16 and (ii) the corresponding herd protection in populations with gender‐equal or traditional sexual behavior and with different levels of sexual activity, corresponding to pre‐vaccination HPV16 prevalence from 1 to 8% as observed worldwide. Between populations with different levels of gender‐equal sexual activity, the highest difference in %PR under girls‐only vaccination is observed at 40% coverage (91%PR vs. 48%PR for 1% and 8% pre‐vaccination prevalence, respectively). HPV16 elimination is obtained with 55 and 97% coverage, respectively. To achieve desirable levels of HPV16 prevalence after vaccination, different levels of coverage are required in populations with different levels of pre‐vaccination HPV16 prevalence, for example, in populations with gender‐equal sexual behavior a decrease to 1/1000 HPV16 from pre‐vaccination prevalence of 1 and 8% would require coverages of 37 and 96%, respectively. In traditional populations, corresponding coverages would need to be 28 and 93%, respectively. In conclusion, pre‐vaccination HPV prevalence strongly influences herd immunity and helps predict the overall effectiveness of HPV vaccination. What's new? Differences in sexual activity from one population to another account for up to a ten‐fold difference in HPV prevalence, which in turn affects cervical‐cancer risk. How do these factors impact the effectiveness of HPV‐vaccination programs? In this epidemiological study, the authors found that, in countries where sexual behavior is based on traditional norms and HPV prevalence remains low, an early introduction of HPV vaccination will anticipate any increase of HPV prevalence among young women due to the liberalization of social attitudes.
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影响因子：
6.4
作者：
de Martel C;Plummer M;Vignat J;Franceschi S
通讯作者：
Franceschi S
影响因子：
51.1
作者：
Kreimer, Aimee R.;Struyf, Frank;Del Rosario-Raymundo, Mora Rowena;Hildeshim, Allan;Skinner, S. Rachel;Wacholder, Sholom;Garland, Suzanne M.;Herrero, Rolando;David, Marfe-Pierre;Mfeeler, Cosette M.
通讯作者：
Mfeeler, Cosette M.
DOI：
10.1158/1940-6207.capr-13-0203
发表时间：
2013-11
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Safaeian M;Porras C;Pan Y;Kreimer A;Schiller JT;Gonzalez P;Lowy DR;Wacholder S;Schiffman M;Rodriguez AC;Herrero R;Kemp T;Shelton G;Quint W;van Doorn LJ;Hildesheim A;Pinto LA;CVT Group
通讯作者：
CVT Group
影响因子：
6.4
作者：
Baussano, Iacopo;Lazzarato, Fulvio;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
影响因子：
3.1
作者：
Hertog, Sara
通讯作者：
Hertog, Sara