Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders.
Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders.
复制标题
DOI：
10.1002/mds.22943
复制
发表时间：
2010-01-30
影响因子：
8.6
通讯作者：
Schupf, Nicole
中科院分区：
文献类型：
--
作者：
Louis, Elan D.;Tang, Ming X.;Schupf, Nicole
有证据表明，轻度帕金森症状（MPS）与痴呆风险增加有关，这表明MPS可能是痴呆的早期生物标志物。在一项新的队列研究中，为了确定(1)基线MPS是否为痴呆发生的预测因子，(2)MPS与痴呆的其他基线危险因素之间是否存在相互作用（即两者同时存在会大大提高痴呆的风险）。在一项前瞻性的纵向研究中，对纽约曼哈顿北部社区居住的老年人进行了帕金森症状的评估，并采用了一种简化的统一帕金森病评定量表。采用Cox比例风险模型评估痴呆发生风险。共有1851名参与者（平均随访3.7年）。基线MPS患者发生痴呆的可能性是无MPS患者的两倍：16.3% vs. 7.7%，未调整的风险比(HR)= 2.24 (p <0.001)，调整后的HR= 1.98 （p <0.001）。MPS分为3个亚型：调整后hr轴功能障碍= 2.45 (p <0.001)，调整后hr震颤= 2.38 (p = 0.006)，调整后hr僵直= 1.16 （p = 0.58）。当MPS作为一个连续变量时，调整后的HR = 1.15 （p = 0.001）。MPS与痴呆的其他基线危险因素（包括性别、教育程度、种族、痴呆家族史、卒中和APOE-e4）之间没有相互作用。基线MPS似乎是痴呆的一个预测指标。因此，这些运动体征可能作为新发痴呆的有用生物标志物。
There is some evidence that mild Parkinsonian signs (MPS) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. In a new cohort, to determine whether (1) baseline MPS are a predictor of incident dementia, (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia). In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson’s Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% vs. 7.7%, unadjusted hazards ratio (HR)= 2.24 (p < 0.001), adjusted HR= 1.98 (p <0.001). MPS were divided into three subtypes: adjusted HRaxial dysfunction = 2.45 (p <0.001), adjusted HRtremor = 2.38 (p = 0.006), and adjusted HRrigidity = 1.16 (p = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (p = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and APOE-e4. Baseline MPS seem to be a predictor of incident dementia. These motor signs might therefore serve as a useful biomarker for emerging dementia.
登录
查看更多内容
影响因子：
8.6
作者：
Louis, ED;Schupf, N;Tang, MX
通讯作者：
Tang, MX
影响因子：
--
作者：
Louis, ED;Tang, MX;Mayeux, R
通讯作者：
Mayeux, R
影响因子：
9.9
作者：
Cosentino, S.;Scarmeas, N.;Stern, Y.
通讯作者：
Stern, Y.
影响因子：
9.9
作者：
deRijk, MC;Rocca, WA;Maraganore, DM
通讯作者：
Maraganore, DM
影响因子：
1.8
作者：
Fleischman, Debra A.;Wilson, Robert S.;Bennett, David A.
通讯作者：
Bennett, David A.