Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting.
Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting.
复制标题
缺乏富含组氨酸的蛋白 2 和 3 的恶性疟原虫寄生虫：准确报告的回顾和建议。
DOI：
10.1186/1475-2875-13-283
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发表时间：
2014-07-22
期刊：
影响因子：
3
通讯作者：
Cunningham J
中科院分区：
文献类型：
--
作者：
Cheng Q;Gatton ML;Barnwell J;Chiodini P;McCarthy J;Bell D;Cunningham J
疟疾快速诊断检测在疟疾病例管理、监测和病例调查中发挥着关键作用。检测性能在很大程度上取决于设计和质量特性，如检测灵敏度、特异性和热稳定性。然而，寄生虫的特征，如RDT靶向抗原的可变或不表达也会影响RDT的性能。在某些地区已报告了缺乏PfHRP 2蛋白（检测恶性疟原虫最常见的靶抗原）的恶性疟原虫寄生虫。因此，准确定位缺乏pfhrp2的恶性疟原虫寄生虫的存在和流行将是重要的一步，以便可以优先选择靶向替代抗原的RDT或显微镜用于这些地区。在此，现有的证据和分子基础上识别疟疾寄生虫缺乏PfHRP2的审查，并提出了一套建议的程序，申请未来的调查缺乏PfHRP2的寄生虫。
Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, surveillance and case investigations. Test performance is largely determined by design and quality characteristics, such as detection sensitivity, specificity, and thermal stability. However, parasite characteristics such as variable or absent expression of antigens targeted by RDTs can also affect RDT performance. Plasmodium falciparum parasites lacking the PfHRP2 protein, the most common target antigen for detection of P. falciparum, have been reported in some regions. Therefore, accurately mapping the presence and prevalence of P. falciparum parasites lacking pfhrp2 would be an important step so that RDTs targeting alternative antigens, or microscopy, can be preferentially selected for use in such regions. Herein the available evidence and molecular basis for identifying malaria parasites lacking PfHRP2 is reviewed, and a set of recommended procedures to apply for future investigations for parasites lacking PfHRP2, is proposed.
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影响因子：
64.5
作者：
POLOGE, LG;RAVETCH, JV
通讯作者：
RAVETCH, JV
影响因子：
3
作者：
Ramutton T;Hendriksen IC;Mwanga-Amumpaire J;Mtove G;Olaosebikan R;Tshefu AK;Onyamboko MA;Karema C;Maitland K;Gomes E;Gesase S;Reyburn H;Silamut K;Chotivanich K;Promnares K;Fanello CI;von Seidlein L;Day NP;White NJ;Dondorp AM;Imwong M;Woodrow CJ
通讯作者：
Woodrow CJ
影响因子：
3.4
作者：
Chilton, D.;Malik, A. N. J.;Chiodini, P. L.
通讯作者：
Chiodini, P. L.
影响因子：
3.7
作者：
Gamboa D;Ho MF;Bendezu J;Torres K;Chiodini PL;Barnwell JW;Incardona S;Perkins M;Bell D;McCarthy J;Cheng Q
通讯作者：
Cheng Q
影响因子：
7
作者：
Dharia, Neekesh V.;Plouffe, David;Winzeler, Elizabeth A.
通讯作者：
Winzeler, Elizabeth A.