Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites.
Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites.
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DOI：
10.3389/fphar.2021.658513
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发表时间：
2021
影响因子：
5.6
通讯作者：
Eid SY
中科院分区：
文献类型：
--
作者：
El-Readi MZ;Al-Abd AM;Althubiti MA;Almaimani RA;Al-Amoodi HS;Ashour ML;Wink M;Eid SY
植物次生代谢物（SM）的常见天然存在和许多SM的显著较低的毒性已经导致这些化合物作为有效的药剂的接近开发和使用;特别是在癌症治疗中。两种或三种植物次生代谢产物的组合或一种SM与特定抗癌药物的组合可以协同地降低所需剂量，拓宽化疗窗口，介导更有效的细胞生长抑制，并避免高药物浓度的副作用。在混合物中，它们可以发挥相加或甚至协同作用。许多SM可以有效地增加癌细胞对化疗的敏感性。在植物治疗中，药用植物的次级代谢产物（SM）可以与单个或多个靶标相互作用。本文综述了植物次生代谢产物克服多药耐药的多分子机制。这些机制包括与膜蛋白如P-糖蛋白（P-gp/MDR 1）、ATP结合盒（ABC）转运蛋白、核酸（DNA、RNA）的相互作用以及诱导细胞凋亡。P-gp在肿瘤细胞MDR的发生发展中起重要作用，并与潜在的化疗失败有关。因此，摄入含有次级代谢产物的膳食补充剂、食物或饮料，多酚或萜类化合物可改变作为P-gp底物的药物的生物利用度、治疗功效和安全性。
Plant secondary metabolites (SMs) common natural occurrences and the significantly lower toxicities of many SM have led to the approaching development and use of these compounds as effective pharmaceutical agents; especially in cancer therapy. A combination of two or three of plant secondary metabolites together or of one SM with specific anticancer drugs, may synergistically decrease the doses needed, widen the chemotherapeutic window, mediate more effective cell growth inhibition, and avoid the side effects of high drug concentrations. In mixtures they can exert additive or even synergistic activities. Many SM can effectively increase the sensitivity of cancer cells to chemotherapy. In phytotherapy, secondary metabolites (SM) of medicinal plants can interact with single or multiple targets. The multi-molecular mechanisms of plant secondary metabolites to overcome multidrug resistance (MDR) are highlighted in this review. These mechanisms include interaction with membrane proteins such as P-glycoprotein (P-gp/MDR1); an ATP-binding cassette (ABC) transporter, nucleic acids (DNA, RNA), and induction of apoptosis. P-gp plays an important role in the development of MDR in cancer cells and is involved in potential chemotherapy failure. Therefore, the ingestion of dietary supplements, food or beverages containing secondary metabolites e.g., polyphenols or terpenoids may alter the bioavailability, therapeutic efficacy and safety of the drugs that are P-gp substrates.
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癌组学对癌症生物标志物发现的贡献。
影响因子：
37.3
作者：
Cho, William C S
通讯作者：
Cho, William C S
DOI：
10.1007/978-1-60761-416-6_15
发表时间：
2010-01-01
期刊：
MULTI-DRUG RESISTANCE IN CANCER
影响因子：
--
作者：
Coley, Helen M.
通讯作者：
Coley, Helen M.
影响因子：
4.6
作者：
Abdalla, Ashraf N.;Abdallah, Mohamed E.;El-Azab, Adel S.
通讯作者：
El-Azab, Adel S.
DOI：
10.1016/s1499-3872(11)60102-1
发表时间：
2011-12-01
影响因子：
3.3
作者：
Cao, Ming-Rong;Li, Qiang;Jiang, Jian-Wei
通讯作者：
Jiang, Jian-Wei
影响因子：
7.3
作者：
Alexander, Stephen P. H.;Kelly, Eamonn;Davies, Jamie A.
通讯作者：
Davies, Jamie A.