The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders.
The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders.
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DOI：
10.3389/fnut.2021.736816
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发表时间：
2021
影响因子：
5
通讯作者：
Kaul R
中科院分区：
文献类型：
--
作者：
Malazogu F;Rousseau RK;Shivappa N;Huibner S;Walmsley SL;Kovacs CM;Benko E;Reinhard RJ;Rosenes R;Hebert JR;Kaul R
免疫无应答者(INR)是一组HIV携带者，尽管接受了有效的抗逆转录病毒治疗(ART)，但血液中CD4+T细胞的恢复情况并不理想。他们患严重非艾滋病共病和死亡的风险增加，并表现出增强的全身免疫活性。在其他人群中，饮食通过饮食炎症指数(DII)与全身炎症标志物相关，但这种相关性尚未在艾滋病毒携带者(PLWH)中进行研究。血采自28INR PLWH，血CD_4~+T细胞计数&350/μ，L，尽管≥治疗2年有效。参与者完成了一份加拿大饮食历史问卷，他们的回答被用来计算DII。用ELISA法测定血浆炎症标志物(干扰素γ、肿瘤坏死因子、白介素6、血管细胞黏附分子、D-二聚体、CD14和C反应蛋白)，用流式细胞仪测定细胞免疫活性(CD4+和CD8+T细胞表面的HLADR和CD38)，计算饮用乳果糖和甘露醇后尿液中乳果糖和甘露醇的比值来评价小肠通透性。受试者年龄中位数为57岁，接受有效抗逆转录病毒治疗15年，DII中位数为−1.91(范围为−3.78至+2.23)。未观察到DII与血浆炎症标志物、T细胞激活水平、肠道通透性或细菌易位生物标志物sCD14之间的相关性。自我报告的酒精摄入量是饮食和炎症生物标志物之间关系的潜在混杂因素，也与全身炎症或肠道通透性无关。我们的发现表明，其他机制，而不是饮食，可能是INR患者全身炎症的主要驱动因素。
Immunologic non-responders (INRs) are a subset of individuals living with HIV who have suboptimal blood CD4+ T cell recovery despite effective antiretroviral therapy (ART). They are at an increased risk of serious non-AIDS co-morbidities and death, and demonstrate enhanced systemic immune activation. In other populations diet has been correlated with markers of systemic inflammation through the Diet Inflammatory Index (DII), but this association has not been studied in persons living with HIV (PLWH). Blood was collected from 28 INR PLWH with a blood CD4+ T cell count <350/μL despite ≥2 years of effective ART. Participants completed a Canadian Diet History Questionnaire, and their responses were used to calculate the DII. Plasma inflammatory markers (IFNγ, TNF, IL-6, sVCAM, D-dimer, sCD14 and CRP) were assayed by ELISA, cellular immune activation (HLA-DR and CD38 on CD4+ and CD8+ T cells) was quantified using flow cytometry, and small bowel permeability assessed by calculation of the urine LacMan ratio after drinking a mix of lactulose and mannitol. Participants were a median age of 57 years, had been on effective ART for 15 years, and the median DII was −1.91 (range of −3.78 to +2.23). No correlation was observed between DII and plasma markers of inflammation, levels of T cell activation, gut permeability, or the biomarker of bacterial translocation sCD14. Self-reported alcohol intake, a potential confounder of the relationship between diet and inflammatory biomarkers, was also not associated with systemic inflammation or gut permeability. Our findings suggest that other mechanisms, rather than diet, are likely to be the major driver of systemic inflammation in INR individuals.
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影响因子：
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作者：
de Koning L;Chiuve SE;Fung TT;Willett WC;Rimm EB;Hu FB
通讯作者：
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影响因子：
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作者：
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DOI：
10.1097/qad.0b013e328352ce54
发表时间：
2012-06-01
期刊：
AIDS (London, England)
影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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