Progression of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.
Progression of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.
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DOI：
10.1167/tvst.12.3.19
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发表时间：
2023-03-01
影响因子：
3
通讯作者：
Hood, Donald C.
中科院分区：
文献类型：
--
作者：
Tsamis, Emmanouil;La Bruna, Sol;Rai, Anvit;Leshno, Ari;Grossman, Jennifer;Cioffi, George;Liebmann, Jeffrey M.;Moraes, Carlos Gustavo;Hood, Donald C.
用于检测青光眼进展的光学相干断层扫描 (OCT) 和视野 (VF) 摘要指标的性能比较。 30 只健康对照眼（平均偏差 [MD]，-1.25 ± 2.03；模式标准差 [PSD]，1.78 ± 0.77）和由 54 名青光眼患者和 37 名青光眼疑似患者组成的 91 只患者眼（MD，-1.58 ± 1.96；PSD，2.82 ± 1.92）组成一组进行评估，随访时间至少为 1 年事件分析的进展（P-Event）。使用至少四次测试的附加标准的眼睛子集进行趋势分析 (P-Trend)（30 名健康对照和 73 名患者）。对于 P 事件分析，通过 4 个月内的重复测试来估计重测变异性阈值（下 5 个百分位数）。如果后续测试和基线测试之间的差异超过变异性阈值，则 P 事件眼被视为“进展者”。对于 P 趋势分析，变化率是根据最小二乘回归计算的。具有显着（P < 0.05）值的阴性率被认为是进展。作为参考标准，根据结构和相应功能进展的明确证据，17 名患者眼睛被归类为明确进展。孤立的 OCT 和 VF 摘要指标要么不够敏感，要么不太具体。 OCT-OCT 和 OCT-VF 指标的组合显着将特异性提高到接近 100%。 OCT 指标（环视乳头视网膜神经纤维层和神经节细胞层）的新型组合显示出高精度，15 个统计进展者中有 13 个被确认为真阳性。尽管不建议出于临床目的仅依赖指标，但在需要非常高特异性和精确度的情况下，可以使用 OCT-OCT 指标的组合。所有可用的 OCT 和 VF 指标都可能会漏掉患有进行性青光眼损伤的眼睛和/或可能错误地识别稳定眼睛的进展情况。
Performance comparison of optical coherence tomography (OCT) and visual field (VF) summary metrics for detecting glaucomatous progression. Thirty healthy control eyes (mean deviation [MD], −1.25 ± 2.03; pattern standard deviation [PSD], 1.78 ± 0.77) and 91 patient eyes comprised of 54 glaucoma patients and 37 glaucoma suspects (MD, −1.58 ± 1.96; PSD, 2.82 ± 1.92) with a follow-up of at least 1 year formed a group to evaluate progression with event analyses (P-Event). A subset of eyes with an additional criterion of a minimum of four tests was used for trend analyses (P-Trend) (30 healthy controls and 73 patients). For P-Event analysis, test–retest variability thresholds (lower 5th percentile) were estimated with repeat tests within a 4-month period. A P-Event eye was considered a “progressor” if the difference between follow-up and baseline tests exceeded the variability thresholds. For the P-Trend analysis, rates of change were calculated based on least-squares regression. Negative rates with significant (P < 0.05) values were considered progressing. For a reference standard, 17 patient eyes were classified as definitely progressing based on clear evidence of structural and corresponding functional progression. Isolated OCT and VF summary metrics were either inadequately sensitive or not too specific. Combinations of OCT–OCT and OCT–VF metrics markedly improved specificity to nearly 100%. A novel combination of OCT metrics (circumpapillary retinal nerve fiber layer and ganglion cell layer) showed high precision, with 13 of the 15 statistical progressors confirmed as true positives. Although relying solely on metrics is not recommended for clinical purposes, in situations requiring very high specificity and precision, combinations of OCT–OCT metrics can be used. All available OCT and VF metrics can miss eyes with progressive glaucomatous damage and/or can falsely identify progression in stable eyes.
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影响因子：
3
作者：
Tsamis E;La Bruna S;Leshno A;De Moraes CG;Hood D
通讯作者：
Hood D
影响因子：
4.4
作者：
Artes, PH;Hutchison, DM;Chauhan, BC
通讯作者：
Chauhan, BC
影响因子：
2.9
作者：
Hood, Donald C.;La Bruna, Sol;Tsamis, Emmanouil;Leshno, Ari;Melchior, Bruna;Grossman, Jennifer;Liebmann, Jeffrey M.;De Moraes, Carlos Gustavo
通讯作者：
De Moraes, Carlos Gustavo
影响因子：
2
作者：
Hood, Donald C.;Zemborain, Zane Z.;De Moraes, Carlos Gustavo
通讯作者：
De Moraes, Carlos Gustavo
影响因子：
4.4
作者：
Hood, Donald C.;Tsamis, Emmanouil;De Moraes, Carlos G.
通讯作者：
De Moraes, Carlos G.