Inconsistency of the slope and the volume intercept of the end-systolic pressure-volume relationship as individual indexes of inotropic state in conscious dogs: presentation of an index combining both variables.
Inconsistency of the slope and the volume intercept of the end-systolic pressure-volume relationship as individual indexes of inotropic state in conscious dogs: presentation of an index combining both variables.
复制标题
收缩末期压力-容积关系的斜率和容积截距作为清醒狗正性肌力状态的各个指标的不一致：提出结合两个变量的指数。
作者：
A. Crottogini;P. Willshaw;J. Barra;R. Armentano;Edmundo;I.;C. Fischer;R. Pichel
我们测试了收缩末期压力-容积关系（ESPVR）的斜率（Emax）和容积截距（Vo）的能力，以指示清醒犬的收缩力变化，这些犬配备了在三个正交轴上测量左心室直径的声速测微计和左心室压力微传感器。在对照条件下（C1和C2），以及分别通过输注多巴酚丁胺和注射普萘洛尔实现的增强（I+）和抑制（I-）正性肌力状态下，通过下腔静脉闭塞产生ESPVR。第一对照组（C1）与I+之间或第二对照组（C2）与I-之间的Emax均无显著差异（C1，5.31 ± 1.68 mm Hg/ml，平均值± SD; I+，5.37 ± 1.44; C2，5.20 ± 1.62; I-，4.18 ± 1.32）或Vo（C1，10.3 +/- 9.6 ml; I+，7.3 +/- 9.1; C2，9.9 +/- 9.0; I-，12.7 +/- 12.5），尽管其他收缩性指标发生了显著变化。比较个体动物对I+和I-反应的Emax变化，发现63%不显著，28%显著和预期，9%显著和矛盾。在规定的体积限度内，无论Emax和Vo的个体变化如何，在所有动物中，I+将ESPVR移到C1的上方和左侧，I-将ESPVR移到C2的下方和右侧。因此，我们通过测量定义的收缩末期容积限值之间的每个ESPVR下方的面积来整合Emax和Vo的变化。面积值为：C1，612 +/- 150 mm Hg.ml; I+，745 +/- 191（p小于.001）; C2，520 +/- 198; I-，420 +/- 139（p小于.001）。我们得出结论：（1）Emax和Vo都不是收缩力变化的独立可靠指标，（2）在定义的收缩末期容积限值之间的ESPVR下方的面积是变力状态变化的一致指标。
We tested the ability of the slope (Emax) and the volume intercept (Vo) of the end-systolic pressure-volume relationship (ESPVR) to indicate contractility changes in conscious dogs instrumented with sonomicrometers measuring left ventricular diameter in three orthogonal axes and a left ventricular pressure microtransducer. ESPVRs were generated by inferior vena caval occlusion under control conditions (C1 and C2) and during enhanced (I+) and depressed (I-) inotropic states achieved by infusion of dobutamine and injection of propranolol, respectively. No significant difference between the first control (C1) and I+ or between the second control (C2) and I- were found for either Emax (C1, 5.31 +/- 1.68 mm Hg/ml, mean +/- SD; I+, 5.37 +/- 1.44; C2, 5.20 +/- 1.62; I-, 4.18 +/- 1.32) or Vo (C1, 10.3 +/- 9.6 ml; I+, 7.3 +/- 9.1; C2, 9.9 +/- 9.0; I-, 12.7 +/- 12.5), despite significant changes in other indexes of contractility. Comparison of changes in Emax in individual animals in response to I+ and I- revealed that 63% were nonsignificant, 28% were significant and expected, and 9% were significant and paradoxical. Within defined volume limits and irrespective of individual changes in Emax and Vo, in all animals I+ shifted the ESPVR above and to the left of C1 and I- shifted the ESPVR below and to the right of C2. We thus integrated the changes in Emax and Vo by measuring the area beneath each ESPVR between defined limits of end-systolic volume. The values for area were: C1, 612 +/- 150 mm Hg.ml; I+, 745 +/- 191 (p less than .001); C2, 520 +/- 198; I-, 420 +/- 139 (p less than .001). We conclude that (1) neither Emax nor Vo are individually reliable indexes of changed contractility, and (2) the area beneath the ESPVR between defined end-systolic volume limits is a consistent indicator of variations in inotropic state.
收缩末压-容积和压力-壁厚度关系在清醒狗中的应用。
影响因子：
24
作者：
Lee,JD;Tajimi,T;Widmann,TF;RossJr,J
通讯作者：
RossJr,J
局部心室性能的收缩末期测量。
影响因子：
37.8
作者：
Aversano,T;Maughan,WL;Hunter,WC;Kass,D;Becker,LC
通讯作者：
Becker,LC
影响因子：
37.8
作者：
KASS, DA;YAMAZAKI, T;SAGAWA, K
通讯作者：
SAGAWA, K