Post-transcriptional gene silencing in plants by RNA
Post-transcriptional gene silencing in plants by RNA
复制标题
RNA在植物中的转录后基因沉默
作者：
Hao Yu;Hao Yu;Prakash P. Kumar
RNA沉默在植物中被称为转录后基因沉默，是由双链RNA诱导的序列特异性核苷酸相互作用的RNA降解过程。在植物中，RNA沉默不仅是防御机制的组成部分，而且在多种发育过程中参与调控内源基因的表达。本文综述了目前对RNA沉默的分子基础的理解进展，包括microRNA调控与RNA沉默之间的机制联系。文章还讨论了RNA沉默作为一种反向遗传学方法在植物功能基因组学中的实际应用。
RNA silencing, which is termed post-transcriptional gene silencing in plants, is an RNA degradation process through sequence-specific nucleotide interactions induced by double-stranded RNA. In plants, RNA silencing not only serves as a component of the defense mechanism, but also participates in the regulation of endogenous gene expression in a variety of developmental processes. This review elaborates the current progress on the understanding of the molecular basis of RNA silencing including a mechanistic link between the regulation of microRNA and RNA silencing. The practical use of RNA silencing as a reverse genetics approach in plant functional genomics is also discussed.
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影响因子：
4.6
作者：
S. Jacobsen;M. Running;E. Meyerowitz
通讯作者：
S. Jacobsen;M. Running;E. Meyerowitz
影响因子：
16
作者：
Slack, FJ;Basson, M;Ruvkun, G
通讯作者：
Ruvkun, G
DOI：
10.1073/pnas.96.9.5049
发表时间：
1999-04-27
影响因子：
11.1
作者：
Alvarado, AS;Newmark, PA
通讯作者：
Newmark, PA
DOI：
10.1073/pnas.060034297
发表时间：
2000-04-25
影响因子：
11.1
作者：
Chuang, CF;Meyerowitz, EM
通讯作者：
Meyerowitz, EM