Channels of the corpus callosum. Evidence from simple reaction times to lateralized flashes in the normal and the split brain.

Channels of the corpus callosum. Evidence from simple reaction times to lateralized flashes in the normal and the split brain.
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胼胝体的通道。

DOI:
10.1093/brain/118.3.779
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发表时间:
1995
期刊:
Brain : a journal of neurology
影响因子:
--
通讯作者:
Zaidel,E
Zaidel,E
中科院分区:
--
文献类型:
--
作者:
Iacoboni,M;Zaidel,E

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我们研究了75名正常受试者和3名共分症患者,使用对偏侧闪光的单一反应时间作为半球间传播时间的行为估计。执行了三种不同版本的范式:(i)基本任务;(ii)运动任务,运动反应的复杂性增加;(iii)视觉任务,视觉刺激呈现的复杂性增加。我们检验了两个假设。首先,简单反应时间任务的新版本导致半球专门化的转移,仅用于处理运动输出(由反应手的主要作用表明)或视觉输入(由视野的主要作用表明),而不影响胼胝体传递。在这种情况下,正常人和裂脑病人在反应手和视野相互作用中不表现出显著的任务,在交叉-非交叉差异相互作用中不表现出显著的任务。第二,新版本的任务影响胼胝体转移。在这种情况下,正常人,而不是脑裂患者,会通过反应手和视野相互作用来显示一个重要的任务,通过交叉-非交叉差异相互作用来显示一个重要的任务。结果与后一种假设一致,表明运动任务通过视野相互作用和交叉-未交叉差异显著改变了反应手,但仅在正常受试者中,可能在服务于半球间转移的胼胝体通道中产生了开关。
We studied 75 normal subjects and three commissurotomized patients using unimanual simple reaction times to lateralized flashes as a behavioural estimate of interhemispheric transmission time. Three different versions of the paradigm were performed: (i) the basic task; (ii) a motor task, with an increased complexity of the motor response; and (iii) a visual task, with an increased complexity of the visual stimulus presentation. We tested two hypotheses. First, that the new versions of the simple reaction time task result in shifts in hemispheric specialization for processing motor output (indicated by a main effect of response hand) or visual input (indicated by a main effect of visual field) alone, without affecting callosal transmission. In that case normals and split brain patients would show no significant task by response hand by visual field interaction and no significant task by crossed-uncrossed difference interaction. Secondly, that the new versions of the task affect callosal transfer. In that case, normals, but not split brain patients, would show a significant task by response hand by visual field interaction and a significant task by crossed-uncrossed difference interaction. Results are consistent with the latter hypothesis, showing that the motor task significantly changed the response hand by visual field interaction and the crossed-uncrossed difference, but only in normal subjects, perhaps producing a switch in the callosal channel subserving the interhemispheric transfer.
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