Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats.
Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats.
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DOI：
10.1016/j.biopsych.2019.05.018
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发表时间：
2019-12-01
影响因子：
10.6
通讯作者：
Shaham Y
中科院分区：
文献类型：
--
作者：
Venniro M;Russell TI;Zhang M;Shaham Y
我们最近报道了操作性社会选择诱导的自愿禁欲可以防止甲基苯丙胺渴望的孵化。在这里，我们确定是否社会选择诱导的自愿禁欲将防止海洛因渴望的孵化。我们还引入了一个全自动的社会奖励自我管理模型，消除了原来的半自动模型的紧张的工作量和鼠-人的互动。在Exp. 1、对雌雄大鼠进行社会自我给药训练（6d）和海洛因自我给药训练（12 d）。接下来，我们评估了1天和15天禁欲后海洛因寻求的复发。在两次测试之间，老鼠要么被迫禁欲，要么接受社会选择诱导的禁欲。在Exp. 2、我们开发了一种全自动的社会自我管理程序，通过在自我管理室和社会同伴室之间引入屏幕;屏幕允许身体接触，但防止大鼠跨越室。接下来，我们比较了具有标准（无屏幕）或自动（屏幕）社会自我管理和社会选择诱导的禁欲历史的大鼠的渴望孵化。停止药物自我管理（潜伏期的渴望）后寻求海洛因的时间依赖性增加是较低的社会选择诱导的禁欲后，比强迫禁欲。在标准半自动程序与新型全自动程序中训练的大鼠中，社会自我管理、社会选择诱导的禁欲和渴望的孵化没有差异。我们的研究表明，奖励的社会互动对海洛因自我管理和海洛因渴望的孵化的保护作用，并介绍了一个全自动的社会自我管理和选择程序，以调查意志社会互动在药物成瘾和其他精神疾病中的作用。
We recently reported that operant social choice-induced voluntary abstinence prevents incubation of methamphetamine craving. Here, we determined whether social choice-induced voluntary abstinence would prevent incubation of heroin craving. We also introduce a fully-automatic social reward self-administration model that eliminates the intense workload and rat-human interaction of the original semi-automatic model. In Exp. 1, we trained male and female rats for social self-administration (6 d) and then for heroin self-administration (12 d). Next, we assessed relapse to heroin seeking after 1 and 15 abstinence days. Between tests, the rats underwent either forced or social choice-induced abstinence. In Exp. 2, we developed a fully-automatic social self-administration procedure by introducing a screen between the self-administration chamber and the social-peer chamber; the screen allows physical contact but prevents rats from crossing chambers. Next, we compared incubation of craving in rats with a history of standard (no-screen) or automatic (screen) social self-administration and social choice-induced abstinence. The time-dependent increase in heroin seeking after cessation of drug self-administration (incubation of craving) was lower after social choice-induced abstinence than after forced abstinence. There were no differences in social self-administration, social choice-induced abstinence, and incubation of craving in rats trained in the standard semi-automatic procedure versus the novel fully-automatic procedure. Our study demonstrates the protective effect of rewarding social interaction on heroin self-administration and incubation of heroin craving and introduces a fully-automatic social self-administration and choice procedure to investigate the role of volitional social interaction in drug addiction and other psychiatric disorders.
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影响因子：
10.6
作者：
Caprioli D;Venniro M;Zeric T;Li X;Adhikary S;Madangopal R;Marchant NJ;Lucantonio F;Schoenbaum G;Bossert JM;Shaham Y
通讯作者：
Shaham Y
影响因子：
15.9
作者：
Baldo BA
通讯作者：
Baldo BA
影响因子：
4.1
作者：
AZRIN, NH
通讯作者：
AZRIN, NH
影响因子：
3.4
作者：
Dunn, Kelly;DeFulio, Anthony;Silverman, Kenneth
通讯作者：
Silverman, Kenneth
影响因子：
10.6
作者：
Bedi, Gillinder;Preston, Kenzie L.;Epstein, David H.;Heishman, Stephen J.;Marrone, Gina F.;Shaham, Yavin;de Wit, Harriet
通讯作者：
de Wit, Harriet