Gestational tissue inflammatory biomarkers at term labor: A systematic review of literature.
Gestational tissue inflammatory biomarkers at term labor: A systematic review of literature.
复制标题
术语中的妊娠组织炎症生物标志物：文献的系统评价。
DOI：
10.1111/aji.12776
复制
发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Menon R
中科院分区：
文献类型：
--
作者：
Hadley EE;Richardson LS;Torloni MR;Menon R
足月分娩的特征是胎儿-母体组织中的炎症超负荷。尽管有大量关于与分娩相关的炎症生物标志物变化的个体研究，但尚不能全面了解它们在每个子宫隔室中的分布，以更好地了解它们对分娩的机械贡献。本系统综述研究了足月分娩时子宫内组织（羊膜、绒毛膜、蜕膜、胎盘和子宫肌层）中报告的促炎和抗炎生物标志物。我们对三个电子数据库中以英文（1980-2016）发表的正常人类足月分娩期间胎儿-母体组织中报告的亲和亲生物标志物（mRNA和/或蛋白质）的研究进行了系统综述。在总共3，712篇引文中，172篇被纳入最终审查。每个组织在足月分娩时表达一组独特的生物标志物，但组织之间存在显著的重叠。在足月分娩时，所有组织均具有共同的IL-6、IL-8、IL-1β、考克斯-2、PGE-2、TNF-α和hCAP 18。常见和独特的炎症生物标志物在足月分娩时在各种胎儿-母体隔室中表达。所有妊娠组织中促炎标志物的增加表明它们在促进分娩中的协调功能作用。在足月分娩的抗炎指标几乎没有报道。
Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intrauterine tissues (amnion, chorion, decidua, placenta and myometrium) at term labor. We conducted a systematic review of studies on pro and antiinflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980–2016), in three electronic data bases. From a total of 3,712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1β, COX-2, PGE-2, TNF-α, and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in proinflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Antiinflammatory markers at term labor are hardly reported.
登录
查看更多内容
影响因子：
9.8
作者：
Behnia, Faranak;Taylor, Brandie D.;Menon, Ramkumar
通讯作者：
Menon, Ramkumar
影响因子：
5.8
作者：
Chan, EC;Fraser, S;Smith, R
通讯作者：
Smith, R
DOI：
10.1016/s1071-5576(96)00042-1
发表时间：
1996-11-01
期刊：
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
影响因子：
--
作者：
Dudley, DJ;Collmer, D;Trautman, MS
通讯作者：
Trautman, MS
DOI：
10.1016/s0002-9378(15)33313-5
发表时间：
1981-01-01
影响因子：
9.8
作者：
FUCHS, AR;HUSSLEIN, P;FUCHS, F
通讯作者：
FUCHS, F
影响因子：
2.9
作者：
Alexander, Helen A.;Sooranna, Suren R.;Johnson, Mark R.
通讯作者：
Johnson, Mark R.