Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women.
Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women.
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DOI：
10.1186/s12933-023-01753-3
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发表时间：
2023-01-30
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
--
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我们的目的是研究绝经后妇女中甘油三酯-葡萄糖指数 (TyG) 与心血管疾病 (CVD) 风险的关系。共有 7741 名参与者符合纳入标准，并被纳入分析。 TyG指数计算为ln(甘油三酯[mg/dL] × 空腹血糖[mg/dL]/2)。根据TyG指数四分位数将参与者分为四组，并以Q1组作为参考组。使用 Kaplan-Meier 曲线比较各组 CVD 的累积发生率。通过 Cox 比例风险模型（风险比 [HR]、95% 置信区间 [CI]）评估 TyG 指数与绝经后妇女 CVD 风险之间的关联。在中位随访 12 年期间，共有 383 名参与者 (4.95%) 发生了心血管疾病。调整潜在混杂因素后，高基线TyG指数（Q4组）与较高的未来CVD风险相关，与Q1组相比，Q4组CVD风险的HR（95% CI）为1.70（1.21-2.38）。亚组分析显示，无论绝经年龄（小于 50 岁；50 岁及以上）和肥胖状况如何，第四季度组与 CVD 风险显着相关。基线时较高的 TyG 指数作为胰岛素抵抗 (IR) 的标志，与绝经后妇女未来罹患 CVD 的较高风险相关。 TyG指数可以作为早期识别绝经后妇女高危个体的简单易行的标记。在线版本包含可在 10.1186/s12933-023-01753-3 获取的补充材料。
We aimed to examine the association of triglyceride-glucose index (TyG) with risk for cardiovascular disease (CVD) among postmenopausal women. A total of 7741 participants met the inclusion criteria, and were included in the analysis. The TyG index was calculated as ln (triglyceride [mg/dL] × fasting blood glucose [mg/dL]/2). The participants were classified into four groups by the quartiles of TyG index, and the Q1 group was used as the reference group. The cumulative incidence of CVD for the groups were compared using the Kaplan–Meier curves. The association between the TyG index and risk of CVD among postmenopausal women was assessed by the Cox proportional hazards models (hazard ratio [HR], 95% confidence intervals [CI]). During a median follow-up of 12 years, a total of 383 (4.95%) participants developed incident CVD. After adjusting for potential confounding factors, a high baseline TyG index (Q4 group) was associated with higher future risk of CVD, the HR (95% CI) of CVD risk was 1.70 (1.21–2.38) in Q4 group compared with the Q1 group. Subgroup analyses showed the Q4 group was significantly associated with the risk of CVD, regardless of age at menopause (younger than 50 years; 50 years and older) and obesity status. Higher TyG index at baseline as a marker of insulin resistance (IR), is associated with higher risk of future CVD among postmenopausal women. The TyG index may serve as a simple and easy marker for early identification of high-risk individuals in the postmenopausal women. The online version contains supplementary material available at 10.1186/s12933-023-01753-3.
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DOI：
10.1016/s0140-6736(20)30925-9
发表时间：
2020-10-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2019 Diseases and Injuries Collaborators
通讯作者：
GBD 2019 Diseases and Injuries Collaborators
成年早期的高甘油三酯-葡萄糖指数与晚年心血管疾病发生率和死亡率相关：来自 CARDIA 研究的见解
影响因子：
9.3
作者：
Xu, Xinghao;Huang, Rihua;Lin, Yifen;Guo, Yue;Xiong, Zhenyu;Zhong, Xiangbin;Ye, Xiaomin;Li, Miaohong;Zhuang, Xiaodong;Liao, Xinxue
通讯作者：
Liao, Xinxue
影响因子：
8.3
作者：
Wu, Shouling;Song, Yongjian;Jonas, Jost B.
通讯作者：
Jonas, Jost B.
影响因子：
4.9
作者：
Lovejoy, J. C.;Champagne, C. M.;Smith, S. R.
通讯作者：
Smith, S. R.
影响因子：
7.1
作者：
Huang, Shue;Li, Junjuan;Gao, Xiang
通讯作者：
Gao, Xiang