Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review.
Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review.
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DOI：
10.1093/cid/ciy443
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发表时间：
2018-11-13
期刊：
影响因子：
--
通讯作者：
Staehelin C
中科院分区：
文献类型：
--
作者：
Kuenzli AB;Marschall J;Schefold JC;Schafer M;Engler OB;Ackermann-Gäumann R;Reineke DC;Suter-Riniker F;Staehelin C
瑞士输入的这两例安第斯汉坦病毒感染病例说明了重症监护医生面临严重汉坦病毒心肺综合征的挑战，以及处理不熟悉且可能人传人的病原体的感染控制和实验室团队面临的挑战。两名从南美洲返回的旅行者被诊断出感染安第斯山脉汉坦病毒，这是汉坦病毒科中唯一已知可在人与人之间传播的成员。我们描述临床病程以及治疗和感染控制措施。虽然两名患者均在数月内表现出高病毒载量（VL）和排毒，但其中一名患者在 1 周内从严重呼吸道疾病中康复，需要无创通气，而第二名患者则出现严重的汉坦病毒心肺综合征，需要体外膜肺氧合 27 天。后一患者的临床病程因严重弥散性血管内凝血伴弥漫性出血而复杂化，需要大量输血，以及多器官衰竭，包括需要肾脏替代治疗。报告了随访前 9 个月的血液、呼吸道分泌物和精液中的 VL 结果。据我们所知，这是欧洲发现的首例安第斯汉坦病毒感染病例。
These 2 cases of Andes hantavirus infection imported to Switzerland illustrate the challenges for intensive care physicians facing severe hantavirus cardiopulmonary syndrome and for the infection control and laboratory teams that deal with an unfamiliar and potentially human-to-human transmissible pathogen. Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. The clinical course in the latter patient was complicated by severe disseminated intravascular coagulopathy with diffuse hemorrhage that necessitated mass transfusions, as well as by multiple organ failure, including the need for renal replacement therapy. Results of VL in blood, respiratory secretions, and semen for the first 9 months of follow-up are reported. To our knowledge, these are the first cases of Andes hantavirus infection detected in Europe.
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影响因子：
12.7
作者：
Maria Bellomo, Carla;Clara Pires-Marczeski, Fanny;Julieta Padula, Paula
通讯作者：
Julieta Padula, Paula
影响因子：
5
作者：
Moraes Figueiredo, Luiz Tadeu;de Souza, William Marciel;Alcira Enria, Delia
通讯作者：
Alcira Enria, Delia
影响因子：
6.4
作者：
Khan, AS;Khabbaz, RF;Ksiazek, TG
通讯作者：
Ksiazek, TG
影响因子：
6.7
作者：
Manigold T;Mori A;Graumann R;Llop E;Simon V;Ferrés M;Valdivieso F;Castillo C;Hjelle B;Vial P
通讯作者：
Vial P
影响因子：
2.7
作者：
Adams MJ;Lefkowitz EJ;King AM;Harrach B;Harrison RL;Knowles NJ;Kropinski AM;Krupovic M;Kuhn JH;Mushegian AR;Nibert M;Sabanadzovic S;Sanfaçon H;Siddell SG;Simmonds P;Varsani A;Zerbini FM;Gorbalenya AE;Davison AJ
通讯作者：
Davison AJ