Plasma taurine is an axonal excitability-translatable biomarker for amyotrophic lateral sclerosis.
Plasma taurine is an axonal excitability-translatable biomarker for amyotrophic lateral sclerosis.
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血浆牛磺酸是肌萎缩侧索硬化症的轴突兴奋性可翻译生物标志物。
DOI：
10.1038/s41598-022-13397-6
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发表时间：
2022-06-01
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
虽然已经报道了肌萎缩侧索硬化症(ALS)的各种体液生物标志物，但目前还没有建立专门反映轴突兴奋性指数异常的生物标志物。采用毛细管电泳联用飞行时间质谱仪和高效液相色谱飞行时间质谱仪对7例ALS患者和20例正常对照的血浆进行了全面的代谢组学分析，并对22例ALS患者进行了与疾病表型的相关性分析。此外，对所有ALS患者进行了运动神经轴突兴奋性的电生理学研究。在肌萎缩侧索硬化症和对照组中，检测到了与骨骼肌代谢直接相关的各种代谢物的水平，如与脂肪酸β氧化和肌酸途径有关的代谢物。前4种代谢物(核糖-5-磷酸、N6-乙酰赖氨酸、达茶碱、3-甲氧基酪氨酸)受试者工作特征曲线分析显示，肌萎缩侧索硬化症组诊断准确率(曲线下面积 = 0.971)高于对照组。此外，层次聚类分析显示牛磺酸水平与强度-持续时间常数相关，强度-持续时间常数是为预测生存而建立的轴突兴奋性指标。在这项研究中，没有发现糖尿病和治疗(利鲁唑和依达拉奉)对这种关系的显著影响。因此，血浆牛磺酸是一种潜在的新型轴突兴奋性可翻译的ALS生物标志物。
Although various body fluid biomarkers for amyotrophic lateral sclerosis (ALS) have been reported, no biomarkers specifically reflecting abnormalities in axonal excitability indices have currently been established. Capillary electrophoresis time-of-flight mass spectrometry and liquid chromatography time-of-flight mass spectrometry were used to perform a comprehensive metabolome analysis of plasma from seven ALS patients and 20 controls, and correlation analysis with disease phenotypes was then performed in 22 other ALS patients. Additionally, electrophysiological studies of motor nerve axonal excitability were performed in all ALS patients. In the ALS and control groups, levels of various metabolites directly associated with skeletal muscle metabolism, such as those involved in fatty acid β-oxidation and the creatine pathway, were detected. Receiver operating characteristic curve analysis of the top four metabolites (ribose-5-phosphate, N6-acetyllysine, dyphylline, 3-methoxytyrosine) showed high diagnostic accuracy (area under the curve = 0.971) in the ALS group compared with the control group. Furthermore, hierarchical cluster analysis revealed that taurine levels were correlated with the strength-duration time constant, an axonal excitability indicator established to predict survival. No significant effects of diabetes mellitus and treatment (Riluzole and Edaravone) on this relationship were detected in the study. Therefore, plasma taurine is a potential novel axonal excitability-translatable biomarker for ALS.
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影响因子：
5.1
作者：
Akca, Gokcen;Yerdelen, Deniz;Uysal, Hilmi
通讯作者：
Uysal, Hilmi
影响因子：
7.4
作者：
Blaise, Benjamin J.;Correia, Goncalo;Ebbels, Timothy M. D.
通讯作者：
Ebbels, Timothy M. D.
影响因子：
14.5
作者：
BOSTOCK, H;SHARIEF, MK;MURRAY, NMF
通讯作者：
MURRAY, NMF
DOI：
10.3109/17482960802566824
发表时间：
2009-10
期刊：
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
影响因子：
--
作者：
Chiò A;Logroscino G;Hardiman O;Swingler R;Mitchell D;Beghi E;Traynor BG;Eurals Consortium
通讯作者：
Eurals Consortium
DOI：
10.1007/978-1-4614-6130-2_2
发表时间：
2013-01-01
期刊：
TAURINE 8, VOL 1: THE NERVOUS SYSTEM, IMMUNE SYSTEM, DIABETES AND THE CARDIOVASCULAR SYSTEM
影响因子：
--
作者：
Kumari, Neeta;Prentice, Howard;Wu, Jang-Yen
通讯作者：
Wu, Jang-Yen