Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population.
Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population.
复制标题
DOI：
10.1289/ehp.9224
复制
发表时间：
2006-11
影响因子：
10.4
通讯作者：
Flemish Environment and Health Study Group
中科院分区：
文献类型：
--
作者：
Dhooge W;van Larebeke N;Koppen G;Nelen V;Schoeters G;Vlietinck R;Kaufman JM;Comhaire F;Flemish Environment and Health Study Group
2，3，7，8-四氯二苯并对二恶英（TCDD）及其相关环境污染物是芳香烃受体（AhR）配体，对实验动物具有生殖和发育毒性。在人类中，生育相关影响的记录较少。本研究的目的是调查血清中二恶英样生物活性和生殖状态参数的男性从一般人群5个月后，在比利时的多氯联苯和二恶英食品污染事件之间的关系。在佛兰芒环境与健康横断面研究（FLEHS）的框架内，我们招募了101名20-40岁的男性，并评估了精子参数，测量了性激素，并收集了一些生活方式因素的信息。此外，我们确定了AhR介导的酶反应引起的个人血清样品，并表示为TCDD当量浓度（CALUX-TEQs）使用一个既定的反式激活试验。年龄（p = 0.04）和频率的鱼（p = 0.02）和鸡蛋（p = 0.001）消费是独立的血清二恶英样活性的正决定因素。校正可能的混杂因素后，我们发现CALUX-TEQ > 16 pg/L增加2倍，总睾酮和游离睾酮分别减少7.1%和6.8%（均p = 0.04）。我们还观察到精液量下降16.0%（p = 0.03），而精子浓度上升了25.2%（p = 0.07）。未发现与精子总数或精子形态相关。这些数据表明，二恶英类化合物与精囊或前列腺的分泌功能的相互作用，可能间接通过对睾酮分泌的影响，在不影响精子发生的水平。
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and some related environmental contaminants are aryl hydrocarbon receptor (AhR) ligands that exert reproductive and developmental toxicity in laboratory animals. In humans, fertility-related effects are less documented. The aim of this study was to investigate the relationship between dioxin-like biological activity in serum and parameters of reproductive status in men from the general population 5 months after a polychlorinated biphenyl and dioxin food-contamination episode in Belgium. In the framework of the cross-sectional Flemish Environment and Health Study (FLEHS), we recruited 101 men 20–40 years of age and evaluated sperm parameters, measured sex hormones, and gathered information on a number of lifestyle factors. In addition, we determined the AhR-mediated enzymatic response elicited by individual serum samples and expressed it as TCDD equivalent concentrations (CALUX-TEQs) using an established transactivation assay. Age (p = 0.04) and the frequency of fish (p = 0.02) and egg (p = 0.001) consumption were independent positive determinants of serum dioxin-like activity. After correcting for possible confounders, we found that a 2-fold increase in CALUX-TEQ > 16 pg/L was associated with a 7.1% and 6.8% (both p = 0.04) decrease in total and free testosterone, respectively. We also observed a more pronounced drop in semen volume of 16.0% (p = 0.03), whereas sperm concentration rose by 25.2% (p = 0.07). No relationship was found with total sperm count or sperm morphology. These data suggest an interaction of dioxin-like compounds with the secretory function of the seminal vesicles or prostate, possibly indirectly through an effect on testosterone secretion, at levels not affecting spermatogenesis as such.
登录
查看更多内容
DOI：
10.1016/s0074-7696(08)60660-9
发表时间：
1990-01-01
期刊：
International review of cytology
影响因子：
--
作者：
Aumuller, G;Seitz, J
通讯作者：
Seitz, J
影响因子：
64.8
作者：
Bernard, A;Hermans, C;Houins, G
通讯作者：
Houins, G
影响因子：
4.1
作者：
Focant, JF;Eppe, G;De Pauw, E
通讯作者：
De Pauw, E
DOI：
10.1080/026520300283351
发表时间：
2000-04-01
影响因子：
2.9
作者：
Birnbaum, LS;Tuomisto, J
通讯作者：
Tuomisto, J
影响因子：
1.9
作者：
Johnson, ES;Shorter, C;Nolan, CJ
通讯作者：
Nolan, CJ