Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer.
Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer.
复制标题
ICAM-1 外显子 6 (E469K) 多态性与结直肠癌分化相关
DOI：
10.1186/1756-9966-28-139
复制
发表时间：
2009-10-13
期刊：
影响因子：
--
通讯作者：
Han M
中科院分区：
文献类型：
--
作者：
Wang QL;Li BH;Liu B;Liu YB;Liu YP;Miao SB;Han Y;Wen JK;Han M
Background
Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and the susceptibility and phenotypical characteristics of colorectal cancer (CRC).
Methods
The polymorphisms at ICAM-1 exon 4 (G241R) and exon 6 (E469K) were detected by PCR with sequence-specific primers. The relationship between specific genotypes of ICAM-1 and differentiation of CRC was evaluated by the histological grade.
Results
We showed only GG genotype of ICAM-1 individuals in either CRC or normal controls. The KK genotype of ICAM-1 K469E was found more frequently than in the controls (P 0.05). Patients with well-differentiated CRC displayed the KK more frequently than those of poor differentiation (P 0.05).
Conclusion
The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC.
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影响因子：
8.6
作者：
Braun, C;Zahn, R;Folwaczny, C
通讯作者：
Folwaczny, C
影响因子：
29.4
作者：
YANG, HY;VORA, DK;ROTTER, JI
通讯作者：
ROTTER, JI
影响因子：
8.4
作者：
Alexiou, D;Karayiannakis, AJ;Tsigris, C
通讯作者：
Tsigris, C
影响因子：
2.7
作者：
Borozdenkova, S;Smith, J;Rose, M
通讯作者：
Rose, M
DOI：
10.1046/j.1365-2370.2002.00277.x
发表时间：
2002-04-01
期刊：
EUROPEAN JOURNAL OF IMMUNOGENETICS
影响因子：
--
作者：
Gbadegesin, RA;Watson, CJ;Webb, NJA
通讯作者：
Webb, NJA