Neuroendocrine and neurochemical measurements in depression.
Neuroendocrine and neurochemical measurements in depression.
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抑郁症的神经内分泌和神经化学测量。
DOI:
10.1176/ajp.138.12.1555
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发表时间:
1981
期刊:
影响因子:
--
通讯作者:
Berger,PA
中科院分区:
文献类型:
--
作者:
Davis,KL;Hollister,LE;Mathe,AA;Davis,BM;Rothpearl,AB;Faull,KF;Hsieh,JY;Barchas,JD;Berger,PA
The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patients were DST positive and 33% had a blunted TSH response. Two biologic variables, the 8 am postdexamethasone cortisol and the postprobenecid CSF 5-hydroxyindoleacetic acid (5-HIAA), accounted for over half of the variance in the behavioral measure, the Hamilton score. Plasma cortisol elevation was associated with high 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion; TSH blunting was associated with low urinary MHPG excretion. Comprehensive biologic measures showed certain significant interrelationships and correlations with the severity of depression.
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