New consensus nomenclature for mammalian keratins.

New consensus nomenclature for mammalian keratins.
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DOI:
10.1083/jcb.200603161
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发表时间:
2006-07-17
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Wright MW
Wright MW
中科院分区:
其他
文献类型:
--
作者:
Schweizer J;Bowden PE;Coulombe PA;Langbein L;Lane EB;Magin TM;Maltais L;Omary MB;Parry DA;Rogers MA;Wright MW

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角蛋白是一种中间的纤维形成蛋白,在上皮细胞中提供机械支持并实现各种附加功能。1982年,一种命名法被设计出来,用来命名当时已知的角蛋白。近年来,人类基因组的系统测序揭示了一些新的角蛋白基因及其编码蛋白的存在。它们的命名不能在原始系统的上下文中得到充分处理。我们提出了一个新的一致的角蛋白基因和蛋白质命名法,它依赖并扩展了1982年的系统,并遵循了人类和小鼠基因组命名委员会发布的指南。这个修订后的命名法适用于功能基因和假基因,虽然是专门为人类角蛋白的完整补充而设计的,但它提供了纳入其他哺乳动物物种的额外角蛋白所需的灵活性。
Keratins are intermediate filament–forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.
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