Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009.
Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009.
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DOI：
10.3346/jkms.2013.28.1.120
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发表时间：
2013-01
影响因子：
4.5
通讯作者：
Enteroviruses Complications Working Group
中科院分区：
文献类型：
--
作者：
Kim SJ;Kim JH;Kang JH;Kim DS;Kim KH;Kim KH;Kim YH;Chung JY;Bin JH;Jung DE;Kim JH;Kim HM;Cheon DS;Kang BH;Seo SY;Enteroviruses Complications Working Group
2009年，大韩民国首次爆发由肠道病毒71型引起的手足口病或疱疹心绞痛。本研究探讨手足口病或幽门螺杆菌并发症的危险因素。对2009年确诊病原性病毒的手足口病或幽门螺杆菌患者进行了回顾性病历审查。本次调查共检查了168名患者。无并发症80例，有并发症88例，死亡2例。肠道病毒C4a亚型最多见，为67例(54.9%)。单因素分析显示，手足口病的发病类型、发热时间>4d、最高体温>39℃、呕吐、头痛、神经系统体征、血糖>10 0 mg/dL、肠道病毒71型为引起并发症的显著危险因素。经多因素Logistic回归分析，头痛(OR10.75；P<；0.001)和神经体征(OR42.76；P<；0.001)是最显著的影响因素。早期发现并适当处理有上述危险因素的患者将是必要的，以获得更好的临床结果。
In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39℃, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.
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