Shape-specific microfabricated particles for biomedical applications: a review.
Shape-specific microfabricated particles for biomedical applications: a review.
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DOI：
10.1007/s13346-022-01143-4
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发表时间：
2022-08
影响因子：
5.4
通讯作者：
Decuzzi, Paolo
中科院分区：
文献类型：
--
作者：
Moore, Thomas L.;Cook, Alexander B.;Belotti, Elena;Palomba, Roberto;Manghnani, Purnima;Spano, Raffaele;Brahmachari, Sayanti;Di Francesco, Martina;Palange, Anna Lisa;Di Mascolo, Daniele;Decuzzi, Paolo
随着时间的推移，控释系统的历史已经发生了变化;从可降解的载药缝线到单片零级释放装置和纳米尺寸的药物递送制剂。科学家们已经调整了这些药物载体的物理化学性质，以优化其在生物医学/制药应用中的性能。特别地，自20世纪80年代以来，已经使用了微米尺寸范围的颗粒药物递送系统。微纳米纤维技术的最新进展，使精确控制颗粒的尺寸和几何形状，在这里，我们回顾了一系列制药应用的微孔板和盘状聚合物颗粒的效用。微孔板被定义为长方体形式的微米级聚合物局部储库装置，而盘状聚合物纳米构建体是具有微米范围内的横截面直径和数百纳米范围内的厚度的盘状聚合物颗粒。这些多用途颗粒可用于治疗多种病理，例如癌症、炎性疾病和血管疾病，通过利用它们的尺寸、形状、物理性质（例如，刚度）和组件材料，以调整它们的功能。这篇综述强调了这些颗粒的设计和制造策略，讨论了它们的应用，并阐述了它们在配方中使用的新趋势。
The storied history of controlled the release systems has evolved over time; from degradable drug-loaded sutures to monolithic zero-ordered release devices and nano-sized drug delivery formulations. Scientists have tuned the physico-chemical properties of these drug carriers to optimize their performance in biomedical/pharmaceutical applications. In particular, particle drug delivery systems at the micron size regime have been used since the 1980s. Recent advances in micro and nanofabrication techniques have enabled precise control of particle size and geometry–here we review the utility of microplates and discoidal polymeric particles for a range of pharmaceutical applications. Microplates are defined as micrometer scale polymeric local depot devices in cuboid form, while discoidal polymeric nanoconstructs are disk-shaped polymeric particles having a cross-sectional diameter in the micrometer range and a thickness in the hundreds of nanometer range. These versatile particles can be used to treat several pathologies such as cancer, inflammatory diseases and vascular diseases, by leveraging their size, shape, physical properties (e.g., stiffness), and component materials, to tune their functionality. This review highlights design and fabrication strategies for these particles, discusses their applications, and elaborates on emerging trends for their use in formulations.
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影响因子：
7.4
作者：
Anselmo AC;Mitragotri S
通讯作者：
Mitragotri S
药物输送系统的临床和商业影响概述。
DOI：
10.1016/j.jconrel.2014.03.053
发表时间：
2014-09-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Anselmo AC;Mitragotri S
通讯作者：
Mitragotri S
影响因子：
5.6
作者：
Chue, P;Eerdekens, M;David, AS
通讯作者：
David, AS
影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
7.5
作者：
Bucciarelli, Paolo;Martinelli, Ida;Mannucci, Pier Mannuccio
通讯作者：
Mannucci, Pier Mannuccio