Growth and health outcomes at school age in HIV-exposed, uninfected Zambian children: follow-up of two cohorts studied in infancy.
Growth and health outcomes at school age in HIV-exposed, uninfected Zambian children: follow-up of two cohorts studied in infancy.
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DOI：
10.1186/s12887-015-0386-8
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发表时间：
2015-06-06
期刊：
影响因子：
2.4
通讯作者：
Filteau S
中科院分区：
文献类型：
--
作者：
Nicholson L;Chisenga M;Siame J;Kasonka L;Filteau S
接触过艾滋病毒、未感染 (HEU) 的儿童的早期生长和健康状况比未接触过艾滋病毒、未感染 (HUU) 的儿童要差，但关于早期接触艾滋病毒的长期影响的信息很少。我们之前招募了两组 HEU 和 HUU 赞比亚婴儿，并记录了与 HUU 儿童相比，HEU 婴儿的生长和健康状况较差。我们对这些队列中的 HEU 和 HUU 儿童在学龄时进行了随访，并比较了他们的生长、健康、急性或慢性疾病的生化标志物以及学校成绩。我们招募了 111 名 HEU 和 279 名 HUU 6-12 岁儿童。我们进行了人体测量，通过问卷调查和临床检查确定健康状况，查看了孩子最近的学校报告，并测量了血压、血红蛋白 (Hb)、HbA1c、葡萄糖、胆固醇和 C 反应蛋白 (CRP)。 HEU 儿童的人体测量指标低于 HUU 儿童，尤其是臀围（年龄和性别调整后的差异 -1.74 cm；95% 置信区间 (CI) -3.24，-0.24；P = 0.023）和中上臂围（调整后的差异 -0.63 cm，95% CI -1.23，-0.04；P = 0.023）。 P = 0.037），并且对体重指数、大腿围和肩胛下皮褶具有边界效应。 HEU 儿童的总脂肪百分比、躯干脂肪百分比和四肢脂肪百分比显着降低。在对 HEU 和 HUU 儿童之间不同的社会人口统计学变量进行调整后，所有人体测量和身体成分差异变得不显着。报告患有轻微疾病并在就诊时接受药物治疗的 HEU 儿童多于 HUU 儿童。各组之间的生化标志物没有差异。即使在对社会经济变量进行调整后，HEU 儿童的数学成绩仍低于 HUU 儿童。尽管 HEU 儿童比 HUU 儿童体型较小且脂肪百分比较低，但这似乎主要是由于他们的社会经济地位较差。学校成绩较低的原因需要进一步研究。本文的在线版本 (doi:10.1186/s12887-015-0386-8) 包含补充材料，可供授权用户使用。
Early growth and health of HIV-exposed, uninfected (HEU) children is poorer than that of their HIV-unexposed, uninfected (HUU) counterparts but there is little information about longer term effects of early HIV exposure. We previously recruited two cohorts of HEU and HUU Zambian infants and documented the poorer infant growth and health of the HEU compared to the HUU children. We followed up HEU and HUU children from these cohorts when they were school-aged and compared their growth, health, biochemical markers of acute or chronic disease, and school grades. We recruited 111 HEU and 279 HUU children aged 6–12 years. We measured anthropometry, determined health by questionnaire and clinical examination, viewed the child’s most recent school report, and measured blood pressure, haemoglobin (Hb), HbA1c, glucose, cholesterol, and C-reactive protein (CRP). Anthropometric measures were lower among HEU than HUU children, significantly so for hip circumference (age- and sex-adjusted difference −1.74 cm; 95 % confidence interval (CI) -3.24, −0.24; P = 0.023) and mid-upper-arm circumference (adjusted difference −0.63 cm, 95 % CI −1.23, −0.04; P = 0.037) and with borderline effects for body mass index, thigh circumference and subscapular skinfolds. HEU children had significantly lower total, trunk, and limb fat percentages. All anthropometric and body composition differences became non-significant after adjustment for sociodemographic variables which differed between HEU and HUU children. More HEU than HUU children reported minor illnesses and were prescribed medication at the time of visit. There were no differences in biochemical markers between groups. HEU children had lower math grades than HUU children even after adjustment for socioeconomic variables. Although HEU children were smaller and had lower percent fat than HUU children, this appeared to be due mainly to their poorer socioeconomic status. Reasons for lower school grades require further research. The online version of this article (doi:10.1186/s12887-015-0386-8) contains supplementary material, which is available to authorized users.
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DOI：
10.1136/bmj.b2393
发表时间：
2009-06-29
期刊：
BMJ (Clinical research ed.)
影响因子：
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