Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic Rhinitis: A Pilot Neuroimaging Study.
Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic Rhinitis: A Pilot Neuroimaging Study.
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过敏性鼻炎患者静息态自发大脑活动的变化：一项神经影像学试点研究
DOI：
10.3389/fnins.2021.697299
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发表时间：
2021
影响因子：
4.3
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Gao Z;Chen X;Xiang R;Zhang W;Tan L;Fan W;Liu P;Lv H;Xu Y
背景变应性鼻炎(AR)是由免疫球蛋白E(IgE)介导的对变应原的免疫反应引起的鼻部炎症性疾病。除了打喷嚏、瘙痒、鼻漏和鼻塞等典型症状外，据报道，行为并发症也与AR的进展有关，如认知障碍、情绪变化、记忆力下降、注意力缺陷、学习成绩差、焦虑和抑郁。最近的人体研究表明，过敏原暴露引起的大脑功能变化可能会促使哮喘患者产生高度的焦虑和情绪反应。但到目前为止，还没有直接证据表明大脑活动和过敏性鼻炎之间的关系。方法采用静息功能磁共振成像(rS-fMRI)技术检测AR患者是否存在脑活动的功能性改变。对20例AR患者和20例年龄、性别相匹配的健康对照(HCS)的rS-fMRI数据进行了低频波动幅度(Alff)和Alff z转换(ZALFF)的测量。结果与正常对照组比较，AR组楔叶前叶(PCUN)的ALFF值降低，扣带回前部(ACC)的ALFF值升高。这些特征的ALFF值与视觉模拟量表(VAS)评分、鼻结膜炎生活质量问卷(RQLQ)评分、RQLQ各分量表和特异性IgE部分相关。结论伴有PCUN活动减退和ACC活动亢进的AR患者存在静息态自发脑活动的改变。AR的脑相关症状可能是改善AR患者生活质量的另一个潜在的临床干预靶点。对大脑活动的进一步关注对于加深对AR的理解是必不可少的。
Background Allergic rhinitis (AR) is an inflammatory disorder of the nose caused by immunoglobulin E (IgE)-mediated immune response to allergens. Apart from the typical symptoms of sneezing, itching, rhinorrhea, and nasal congestion, behavioral complications were also reported to be associated with the progression of AR, such as cognitive deficits, mood changes, memory decline, attention deficiency, poor school performance, anxiety, and depression. Recent human studies have suggested that alterations in brain function caused by allergen exposure may precipitate high levels of anxiety and emotional reactivity in asthma patients. But until now, there is no direct evidence of the relationship between brain activity and allergic rhinitis. Methods Resting-state functional magnetic resonance imaging (rs-fMRI) was used to excavate whether there remain functional changes of brain activity in AR patients. We measured the amplitude of low-frequency fluctuation (ALFF) and the z conversion of ALFF (zALFF) in 20 patients with AR and 20 age- and sex-matched healthy controls (HCs) using the rs-fMRI data. Results Compared with healthy controls, AR patients exhibited lower ALFF values in the precuneus (PCUN) and higher ALFF values in the anterior cingulate cortex (ACC). The ALFF values of these features were significantly correlated with the visual analog scale (VAS) scores, the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores, the subscales of RQLQ, and specific IgE, partly. Conclusion We found changes in resting-state spontaneous brain activity in AR patients with hypoactivity in the PCUN and hyperactivity of the ACC. The brain-related symptoms of AR might be another potential clinical intervention target for improving the life quality of AR patients. Further attention to brain activity is essential for a deeper understanding of AR.
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DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
4.1
作者：
Gelders G;Baekelandt V;Van der Perren A
通讯作者：
Van der Perren A
影响因子：
2.6
作者：
Feng, Bohai;Jin, Haiyong;Chen, Bobei
通讯作者：
Chen, Bobei
影响因子：
3.1
作者：
Bauer, Jochen;Werner, Anne;Ohrmann, Patricia
通讯作者：
Ohrmann, Patricia