T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
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T-Bet 和 Eomes 调节效应/中央记忆 T 细胞与记忆干样 T 细胞之间的平衡
DOI：
10.1371/journal.pone.0067401
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lu B
中科院分区：
文献类型：
--
作者：
Li G;Yang Q;Zhu Y;Wang HR;Chen X;Zhang X;Lu B
记忆T细胞由效应细胞、中枢细胞和记忆干细胞组成。先前的研究表明，T-bet 和 Eomes 都参与效应和中央记忆 CD8 T 细胞的生成。这些转录因子在塑造记忆 T 细胞库中的确切作用尚不清楚，尤其是记忆干 T 细胞。在这里，我们证明 T-bet 或 Eomes 都是通过过继转移的 CD8 T 细胞消除已形成的肿瘤所必需的。我们还研究了 T-bet 和 Eomes 在过继转移后生成肿瘤特异性记忆 T 细胞亚群中的作用。我们发现，T-bet 和 Eomes 联合缺陷导致效应/中枢记忆 T 细胞数量严重减少，但 CD62LhighCD44low Sca-1+ T 细胞的百分比增加，这与记忆干 T 细胞的表型相似。尽管保留了大量表型记忆干T细胞，但T-bet和Eomes的缺乏导致抗肿瘤记忆反应的严重缺陷，这表明T-bet和Eomes对于这些记忆T细胞的抗肿瘤功能至关重要。我们的研究表明，T-bet 和 Eomes 合作促进效应/中央记忆 CD8 T 细胞相对于记忆干细胞样 T 细胞的表型。
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells. The exact role of these transcription factors in shaping the memory T cell pool is not well understood, particularly with memory stem T cells. Here, we demonstrate that both T-bet or Eomes are required for elimination of established tumors by adoptively transferred CD8 T cells. We also examined the role of T-bet and Eomes in the generation of tumor-specific memory T cell subsets upon adoptive transfer. We showed that combined T-bet and Eomes deficiency resulted in a severe reduction in the number of effector/central memory T cells but an increase in the percentage of CD62LhighCD44low Sca-1+ T cells which were similar to the phenotype of memory stem T cells. Despite preserving large numbers of phenotypic memory stem T cells, the lack of both of T-bet and Eomes resulted in a profound defect in antitumor memory responses, suggesting T-bet and Eomes are crucial for the antitumor function of these memory T cells. Our study establishes that T-bet and Eomes cooperate to promote the phenotype of effector/central memory CD8 T cell versus that of memory stem like T cells.
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影响因子：
4.3
作者：
Kato, Koji;Cui, Shuaiying;Kuick, Rork;Mineishi, Shin;Hexner, Elizabeth;Ferrara, James L. M.;Emerson, Stephen G.;Zhang, Yi
通讯作者：
Zhang, Yi
DOI：
10.1038/nri3191
发表时间：
2012-03-22
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Restifo NP;Dudley ME;Rosenberg SA
通讯作者：
Rosenberg SA
影响因子：
82.9
作者：
Gattinoni L;Lugli E;Ji Y;Pos Z;Paulos CM;Quigley MF;Almeida JR;Gostick E;Yu Z;Carpenito C;Wang E;Douek DC;Price DA;June CH;Marincola FM;Roederer M;Restifo NP
通讯作者：
Restifo NP
影响因子：
30.5
作者：
Intlekofer, AM;Takemoto, N;Reiner, SL
通讯作者：
Reiner, SL
在不受欢迎的记忆CD8+ T细胞的异常分化中T-BET的需求。
DOI：
10.1084/jem.20070841
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Intlekofer AM;Takemoto N;Kao C;Banerjee A;Schambach F;Northrop JK;Shen H;Wherry EJ;Reiner SL
通讯作者：
Reiner SL