The relationship between fertility and lifespan in humans.
The relationship between fertility and lifespan in humans.
复制标题
人类生育能力与寿命之间的关系。
DOI：
10.1007/s11357-010-9202-4
复制
发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Tiemeier, Henning
中科院分区：
文献类型：
--
作者：
Kuningas, Maris;Altmae, Signe;Uitterlinden, Andre G.;Hofman, Albert;van Duijn, Cornelia M.;Tiemeier, Henning
衰老的进化理论预测生育率和寿命之间存在权衡，寿命的延长是以生育率降低为代价的。这一预测得到了各种来源的支持。然而，哪些基因构成了这种关系尚不清楚。为了对其进行评估，我们首先分析了鹿特丹研究中 3,575 名已婚女性参与者的生育能力与初潮和绝经年龄以及死亡率的关系。此外，我们还进行了一项候选基因研究，分析了 25 个候选基因中的 1,664 个单核苷酸多态性 (SNP) 与作为生育能力衡量标准的儿童数量的关系。分析与生育力相关的 SNP 与死亡率的关系。我们观察到生育力与初潮年龄 (p = 0.38) 和更年期年龄 (p = 0.07) 之间没有关联。相反，生育率与死亡率相关。与没有孩子的女性相比，有两到三个孩子的女性死亡率显着降低（风险比 (HR)，0.82；95% 置信区间 (95% CI)，0.69–0.97）。对于有四个或更多孩子的女性来说，没有观察到这种益处，她们与没有孩子的女性有相似的死亡风险（HR，0.93；95% CI，0.76-1.13）。对候选基因的分析显示，经过多重测试校正后，有四个影响生育力的基因：CGB/LHB基因簇（p = 0.0036）、FSHR（p = 0.023）、FST（p = 0.023）和INHBA（p = 0.021）。然而，这些基因中没有一个独立的 SNP 可以预测死亡率。总之，生育两到三个孩子的女性比不生育或生育多个孩子的女性寿命更长，但这种关系并不是由本研究中分析的候选基因介导的。本文的在线版本 (doi:10.1007/s11357-010-9202-4) 包含补充材料，可供授权用户使用。
Evolutionary theories of aging predict a trade-off between fertility and lifespan, where increased lifespan comes at the cost of reduced fertility. Support for this prediction has been obtained from various sources. However, which genes underlie this relationship is unknown. To assess it, we first analyzed the association of fertility with age at menarche and menopause, and with mortality in 3,575 married female participants of the Rotterdam Study. In addition, we conducted a candidate gene study where 1,664 single nucleotide polymorphisms (SNPs) in 25 candidate genes were analyzed in relation to number of children as a measure of fertility. SNPs that associated with fertility were analyzed for association with mortality. We observed no associations between fertility and age at menarche (p = 0.38) and menopause (p = 0.07). In contrast, fertility was associated with mortality. Women with two to three children had significantly lower mortality (hazard ratio (HR), 0.82; 95% confidence interval (95% CI), 0.69–0.97) compared to women with no children. No such benefit was observed for women with four or more children, who had a similar mortality risk (HR, 0.93; 95% CI, 0.76–1.13) as women with no children. The analysis of candidate genes revealed four genes that influence fertility after correction for multiple testing: CGB/LHB gene cluster (p = 0.0036), FSHR (p = 0.023), FST (p = 0.023), and INHBA (p = 0.021). However, none of the independent SNPs in these genes predicted mortality. In conclusion, women who bear two to three children live longer than those who bear none or many children, but this relationship was not mediated by the candidate genes analyzed in this study. The online version of this article (doi:10.1007/s11357-010-9202-4) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.1098/rstb.1991.0028
发表时间：
1991-04-29
影响因子：
6.3
作者：
KIRKWOOD, TBL;ROSE, MR
通讯作者：
ROSE, MR
影响因子：
2.4
作者：
Doblhammer, G
通讯作者：
Doblhammer, G
影响因子：
4.1
作者：
Nagirnaja, Liina;Rull, Kristiina;Uuskuela, Liis;Hallast, Pille;Grigorova, Marina;Laan, Maris
通讯作者：
Laan, Maris
影响因子：
4.5
作者：
Corbo, Rosa Maria;Ulizzi, Laura;Scacchi, Renato
通讯作者：
Scacchi, Renato
影响因子：
4.9
作者：
PARAZZINI, F;NEGRI, E;LAVECCHIA, C
通讯作者：
LAVECCHIA, C