Mitochondrial genome evolution in the Saccharomyces sensu stricto complex.

Mitochondrial genome evolution in the Saccharomyces sensu stricto complex.
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严格酵母复合体中的线粒体基因组进化

DOI:
10.1371/journal.pone.0183035
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
Jiang H
Jiang H
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Ruan J;Cheng J;Zhang T;Jiang H

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探索线粒体基因组的进化模式对于我们理解严格意义上的酵母(Saccharomycesensustricto,SSS)群体是基因组进化和生态分析的模型系统具有重要意义。在本研究中,我们首次获得了两个重要物种,酿酒酵母miklovii和酵母kudriavzevii的线粒体全序列。然后,我们将SSS组中的线粒体基因组与近亲的线粒体基因组进行了比较,发现非编码区进化迅速,包括基因间区域的急剧扩展,内含子的快速进化以及比核基因组高近20倍的重排率。然而,编码区,特别是蛋白质编码基因,比SSS组的核基因组中的那些更保守。线粒体和核基因组编码区和非编码区的不同进化模式可能与该群体有氧发酵生活方式的起源有关。因此,我们的分析为线粒体基因组的进化提供了新的见解。
Exploring the evolutionary patterns of mitochondrial genomes is important for our understanding of the Saccharomyces sensu stricto (SSS) group, which is a model system for genomic evolution and ecological analysis. In this study, we first obtained the complete mitochondrial sequences of two important species, Saccharomyces mikatae and Saccharomyces kudriavzevii. We then compared the mitochondrial genomes in the SSS group with those of close relatives, and found that the non-coding regions evolved rapidly, including dramatic expansion of intergenic regions, fast evolution of introns and almost 20-fold higher rearrangement rates than those of the nuclear genomes. However, the coding regions, and especially the protein-coding genes, are more conserved than those in the nuclear genomes of the SSS group. The different evolutionary patterns of coding and non-coding regions in the mitochondrial and nuclear genomes may be related to the origin of the aerobic fermentation lifestyle in this group. Our analysis thus provides novel insights into the evolution of mitochondrial genomes.
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影响因子: 3.3
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