The Mediodorsal Thalamus: An Essential Partner of the Prefrontal Cortex for Cognition.
The Mediodorsal Thalamus: An Essential Partner of the Prefrontal Cortex for Cognition.
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DOI：
10.1016/j.biopsych.2017.11.008
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发表时间：
2018-04-15
影响因子：
10.6
通讯作者：
Kellendonk C
中科院分区：
文献类型：
--
作者：
Parnaudeau S;Bolkan SS;Kellendonk C
Deficits in cognition are a core feature of many psychiatric conditions, including schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome. Impairment in cognitive domains, such as working memory and behavioral flexibility, have classically been associated with prefrontal cortex (PFC) dysfunction. However, there is increasing evidence that the PFC cannot be dissociated from its main thalamic counterpart, the mediodorsal thalamus (MD). Since the causal relationships between MD-PFC abnormalities and cognitive impairment, as well as the neuronal mechanisms underlying them, are difficult to address in humans, animal models have been employed for mechanistic insight. In this review, we discuss anatomical, behavioral, and electrophysiological findings from animal studies that provide a new understanding on how MD-PFC circuits support higher-order cognitive function. We argue that the MD may be required for amplifying and sustaining cortical representations under different behavioral conditions. These findings advance a new framework for the broader involvement of distributed thalamo-frontal circuits in cognition and point to the MD as a potential therapeutic target for improving cognitive deficits in schizophrenia and other disorders.
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影响因子：
7.6
作者：
Biezonski, Dominik;Cha, Jiook;Posner, Jonathan
通讯作者：
Posner, Jonathan
DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/s0163-1047(89)91000-5
发表时间：
1989-05-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
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作者：
BERACOCHEA, DJ;JAFFARD, R;JARRARD, LE
通讯作者：
JARRARD, LE
影响因子：
1.9
作者：
Burk, JA;Mair, RG
通讯作者：
Mair, RG
DOI：
10.1523/jneurosci.1521-08.2008
发表时间：
2008-10-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clarke HF;Robbins TW;Roberts AC
通讯作者：
Roberts AC