Emerging functions of circular RNA in the regulation of adipocyte metabolism and obesity.
Emerging functions of circular RNA in the regulation of adipocyte metabolism and obesity.
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环状RNA在脂肪细胞代谢和肥胖调节中的新功能
DOI：
10.1038/s41420-022-01062-w
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发表时间：
2022-05-20
影响因子：
7
通讯作者：
Li, Mingxun
中科院分区：
文献类型：
--
作者：
Zhang, Yuanyuan;Tian, Zhichen;Ye, Haibo;Sun, Xiaomei;Zhang, Huiming;Sun, Yujia;Mao, Yongjiang;Yang, Zhangping;Li, Mingxun
As noncoding RNAs, circular RNAs (circRNAs) are covalently enclosed endogenous biomolecules in eukaryotes that have tissue specificity and cell specificity. circRNAs were once considered a rare splicing byproduct. With the development of high-throughput sequencing, it has been confirmed that they are expressed in thousands of mammalian genes. To date, only a few circRNA functions and regulatory mechanisms have been verified. Adipose is the main tissue for body energy storage and energy supply. Adipocyte metabolism is a physiological process involving a series of genes and affects biological activities in the body, such as energy metabolism, immunity, and signal transmission. When adipocyte formation is dysregulated, it will cause a series of diseases, such as atherosclerosis, obesity, fatty liver, and diabetes. In recent years, many noncoding RNAs involved in adipocyte metabolism have been revealed. This review provides a comprehensive overview of the basic structure and biosynthetic mechanism of circRNAs, and further discusses the circRNAs related to adipocyte formation in adipose tissue and liver. Our review will provide a reference for further elucidating the genetic regulation mechanism of circRNAs involved in adipocyte metabolism.
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