Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study.
Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study.
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DOI：
10.1371/journal.pone.0096911
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhou B
中科院分区：
文献类型：
--
作者：
Shen L;Yin Z;Wu W;Ren Y;Li X;Zhou B
共济失调-毛细血管扩张症突变（ATM）基因在DNA双链断裂修复途径中起重要作用。DNA修复基因的单核苷酸多态性（SNP）被怀疑会影响肺癌的风险。本研究旨在探讨ATM-111 G>A（rs 189037）基因多态性、环境危险因素与中国女性非吸烟者肺腺癌发病风险的关系。对487例肺癌患者和516例匹配的无癌对照进行了一项以医院为基础的病例对照研究。有关人口和环境的危险因素的信息，获得了每一个案件和控制由一个训练有素的采访。获得知情同意后，从每例受试者采集10 ml静脉血用于生物标志物检测。采用TaqMan方法检测单核苷酸多态性。本研究表明，ATM rs 189037 AA基因型个体患肺腺癌的风险高于GA或GG基因型个体（调整后比值比（OR）1.44，95%可信区间（CI）1.02-2.02，P = 0.039）。 分层分析显示，ATM rs 189037 AA基因型在从不接触或很少接触烹调油烟的个体中，其危险性增加（校正OR 1.89，95%CI 1.03-3.49，P = 0.040）。 ATM rs 189037可能与中国非吸烟女性肺腺癌的发病风险相关。ATM rs 189037 AA基因型可能是非吸烟女性肺癌的危险因素。
The ataxia-telangiectasia mutated (ATM) gene plays an important role in the DNA double-strand breaks repair pathway. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence the risk of lung cancer. This study aimed to investigate the association between the ATM -111G>A (rs189037) polymorphism, environmental risk factors and the risk of lung adenocarcinoma in Chinese female non-smokers. A hospital-based case-control study of 487 lung cancer patients and 516 matched cancer-free controls was conducted. Information concerning demographic and environmental risk factors was obtained for each case and control by a trained interviewer. After informed consent was obtained, 10 ml venous blood was collected from each subject for biomarker testing. Single nucleotide polymorphism was determined by using TaqMan method. This study showed that the individuals with ATM rs189037 AA genotype were at an increased risk for lung adenocarcinoma compared with those carrying the GA or GG genotype (adjusted odds ratios (OR) 1.44, 95% confidence interval (CI) 1.02–2.02, P = 0.039). The stratified analysis suggested that increased risk associated with ATM rs189037 AA genotype in individuals who never or seldom were exposed to cooking oil fumes (adjusted OR 1.89, 95%CI 1.03–3.49, P = 0.040). ATM rs189037 might be associated with the risk of lung adenocarcinoma in Chinese non-smoking females. Furthermore, ATM rs189037 AA genotype might be a risk factor of lung adenocarcinoma among female non-smokers without cooking oil fume exposure.
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DOI：
10.3779/j.issn.1009-3419.2005.04.06
发表时间：
2005-08-20
期刊：
Zhongguo fei ai za zhi = Chinese journal of lung cancer
影响因子：
--
作者：
Shi, Hailong;He, Qincheng;Zhou, Baosen
通讯作者：
Zhou, Baosen
影响因子：
13.6
作者：
Menzaghi, Claudia;Paroni, Giulia;Trischitta, Vincenzo
通讯作者：
Trischitta, Vincenzo
影响因子：
1.8
作者：
Wang, Chung-Hsing;Wu, Kang-Hsi;Bau, Da-Tian
通讯作者：
Bau, Da-Tian
影响因子：
9.8
作者：
Gilad, S;Chessa, L;Bar-Shira, A
通讯作者：
Bar-Shira, A
ATM 启动子中的功能性单核苷酸多态性与长寿相关。
影响因子：
5.3
作者：
Chen, Tie;Dong, Birong;Mo, Xianming
通讯作者：
Mo, Xianming