High rate of thiamine deficiency among inpatients with cancer referred for psychiatric consultation: results of a single site prevalence study.
High rate of thiamine deficiency among inpatients with cancer referred for psychiatric consultation: results of a single site prevalence study.
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DOI：
10.1002/pon.4155
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发表时间：
2017-09
期刊：
影响因子：
3.6
通讯作者：
Breitbart, William
中科院分区：
文献类型：
--
作者：
Isenberg-Grzeda, Elie;Shen, Megan Johnson;Alici, Yesne;Wills, Jonathan;Nelson, Christian;Breitbart, William
硫胺素缺乏症（TD）越来越多地被医学疾病患者所认识。TD在癌症患者中的患病率尚不清楚。本研究旨在描述住院癌症患者中TD的患病率。回顾性病历审查的病人承认，一个大型癌症中心，谁是精神科咨询和血清硫胺素浓度测定。排除饮酒患者。在217例不同类型癌症患者中，TD的检出率为55.3%。风险因素包括氟尿嘧啶为基础的化疗，显着的体重减轻，并接受积极的癌症治疗。几乎所有的患者体重正常，超重或肥胖，很少有伴随维生素B12或叶酸缺乏症。总共有17.5%的人正在接受多种维生素补充剂。近一半（49.8%）未接受经验性硫胺素治疗，在接受经验性硫胺素治疗的患者中，大多数病例（59.6%）发生治疗延迟。只有10.6%的病例在精神科会诊前测量血清硫胺素浓度。我们的研究结果表明，TD是高度流行的住院癌症患者，即使在正常和超重的个人，在没有其他维生素缺乏症，而接受多种维生素补充剂。确定了几个潜在的风险因素，包括积极的癌症治疗。TD的评价通常不是由肿瘤学家发起的。治疗失败和治疗延迟是常见的。鉴于这些发现，肿瘤学家必须警惕在住院癌症患者中检测TD。
Thiamine deficiency (TD) is increasingly recognized in medically ill patients. The prevalence of TD among cancer patients is unknown. This study aims to characterize the prevalence of TD among inpatients with cancer. Retrospective chart review of patients admitted to a large cancer center who were referred for psychiatric consultation and whose serum thiamine concentration was measured. Patients with alcohol use were excluded. Among 217 patients with various cancer types, TD was found in 55.3%. Risk factors included fluorouracil-based chemotherapy, significant weight loss, and undergoing active cancer treatment. Almost all patients were normal weight, overweight, or obese, and few had concomitant vitamin B12 or folate deficiency. A total of 17.5% were receiving multivitamin supplementation. Nearly half (49.8%) did not receive empiric treatment with thiamine and among those who did, treatment delay occurred in the majority of cases (59.6%). Measurement of serum thiamine concentration preceded psychiatric consultation in only 10.6% of cases. Our findings suggest that TD is highly prevalent among inpatients with cancer, even among normal and overweight individuals, in the absence of other vitamin deficiencies, and while receiving multivitamin supplements. Several potential risk factors were identified, including active cancer treatment. Evaluation of TD was most commonly not initiated by oncologists. Failure to treat and treatment delay were common. Given these findings, oncologists must be vigilant about detecting TD among inpatients with cancer.
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影响因子：
3.4
作者：
Isenberg-Grzeda E;Alici Y;Hatzoglou V;Nelson C;Breitbart W
通讯作者：
Breitbart W
影响因子：
5.1
作者：
Seligmann, H;Levi, R;Prokocimer, M
通讯作者：
Prokocimer, M
影响因子：
8.4
作者：
AKSOY, M;BASU, TK;DICKERSON, JWT
通讯作者：
DICKERSON, JWT
影响因子：
24
作者：
Hanninen, SA;Darling, PB;Keith, ME
通讯作者：
Keith, ME
影响因子：
2.7
作者：
Falder, Sian;Silla, Robyn;Fear, Mark W.
通讯作者：
Fear, Mark W.