Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery.
Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery.
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DOI：
10.1016/j.jpain.2013.09.015
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发表时间：
2014-02
期刊：
影响因子：
4
通讯作者：
Aouizerat, Bradley E.
中科院分区：
文献类型：
--
作者：
Stephens, Kimberly;Cooper, Bruce A.;West, Claudia;Paul, Steven M.;Baggott, Christina R.;Merriman, John D.;Dhruva, Anand;Kober, Kord M.;Langford, Dale J.;Leutwyler, Heather;Luce, Judith A.;Schmidt, Brian L.;Abrams, Gary M.;Elboim, Charles;Hamolsky, Deborah;Levine, Jon D.;Miaskowski, Christine;Aouizerat, Bradley E.
乳腺癌手术后的持续疼痛是一个重要的临床问题。虽然免疫机制可能在持续性疼痛的发生和维持中发挥作用，但很少有研究评估乳腺癌手术后持续性乳房疼痛与细胞因子基因变异之间的关联。在这项研究中，评估了先前确定的极端持续性乳房疼痛表型（即无痛与重度疼痛）与跨越 15 个细胞因子基因的单核苷酸多态性 (SNP) 之间的关联。在未经调整的分析中，7 个基因中的 13 个 SNP 和 3 个单倍型的频率在无痛和重度疼痛类别之间存在显着差异。在调整术前乳房疼痛和平均术后疼痛的严重程度后，一种 SNP（即白细胞介素 (IL) 1 受体 2 rs11674595）和一种单倍型（即 IL10 单倍型 A8）与疼痛组成员资格相关。这些发现表明细胞因子基因多态性在乳腺癌手术后持续性乳房疼痛的发展中发挥作用。这项研究评估了乳腺癌手术后女性细胞因子基因变异与持续性乳房疼痛严重程度之间的关联。两种细胞因子基因的变异与严重的乳房疼痛有关。结果表明细胞因子在持续性术后疼痛的发生中发挥作用。
Persistent pain following breast cancer surgery is a significant clinical problem. While immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (i.e., no pain versus severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, one SNPs (i.e., interleukin (IL) 1 receptor 2 rs11674595) and one haplotype (i.e., IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery. This study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in two cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.
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影响因子：
120.7
作者：
Gartner, Rune;Jensen, Maj-Britt;Kehlet, Henrik
通讯作者：
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影响因子：
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作者：
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McCarthy, MI
DOI：
10.1073/pnas.0409225102
发表时间：
2005-02-01
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作者：
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作者：
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