Diffusion-weighted magnetic resonance imaging to assess diffuse renal pathology: a systematic review and statement paper.
Diffusion-weighted magnetic resonance imaging to assess diffuse renal pathology: a systematic review and statement paper.
复制标题
DOI：
10.1093/ndt/gfy163
复制
发表时间：
2018-09-01
期刊：
影响因子：
--
通讯作者：
Vallée JP
中科院分区：
文献类型：
--
作者：
Caroli A;Schneider M;Friedli I;Ljimani A;De Seigneux S;Boor P;Gullapudi L;Kazmi I;Mendichovszky IA;Notohamiprodjo M;Selby NM;Thoeny HC;Grenier N;Vallée JP
扩散加权磁共振成像（DWI）是一种对组织中局部水分运动敏感的非侵入性方法。作为一种探测微观结构的工具，包括肾脏纤维化的存在和潜在的程度，DWI有可能成为一种有效的成像生物标志物。本文旨在探讨弥漫性肾脏疾病中肾脏DWI的现状。DWI生物标志物可分为以下三大类：(i)表观扩散系数——组织中水分扩散和微循环的总体度量；（ii）真扩散、假扩散和流动部分——提供关于扩散和灌注或管状流动的单独信息；分数各向异性——测量显微组织取向。本文概述了在肾脏弥漫性病变中应用DWI的人类研究，不仅证明了DWI的可行性和研究内的可重复性，还强调了方法标准化、额外验证和鉴定的必要性。本文综述了肾DWI在临床实践中的当前和未来作用，强调了其作为慢性肾脏疾病间质纤维化的替代和监测生物标志物的潜力，以及急性肾脏疾病炎症的替代生物标志物，这可能影响急性移植排斥反应患者选择肾活检。作为国际COST（欧洲科学与技术合作）行动PARENCHIMA（慢性肾脏疾病磁共振成像生物标志物）的一部分，旨在消除临床使用功能性肾脏磁共振成像的障碍，本文为临床研究的未来设计和临床实践中肾脏DWI的使用提供了实用的建议。
Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive method sensitive to local water motion in the tissue. As a tool to probe the microstructure, including the presence and potentially the degree of renal fibrosis, DWI has the potential to become an effective imaging biomarker. The aim of this review is to discuss the current status of renal DWI in diffuse renal diseases. DWI biomarkers can be classified in the following three main categories: (i) the apparent diffusion coefficient—an overall measure of water diffusion and microcirculation in the tissue; (ii) true diffusion, pseudodiffusion and flowing fraction—providing separate information on diffusion and perfusion or tubular flow; and (iii) fractional anisotropy—measuring the microstructural orientation. An overview of human studies applying renal DWI in diffuse pathologies is given, demonstrating not only the feasibility and intra-study reproducibility of DWI but also highlighting the need for standardization of methods, additional validation and qualification. The current and future role of renal DWI in clinical practice is reviewed, emphasizing its potential as a surrogate and monitoring biomarker for interstitial fibrosis in chronic kidney disease, as well as a surrogate biomarker for the inflammation in acute kidney diseases that may impact patient selection for renal biopsy in acute graft rejection. As part of the international COST (European Cooperation in Science and Technology) action PARENCHIMA (Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease), aimed at eliminating the barriers to the clinical use of functional renal magnetic resonance imaging, this article provides practical recommendations for future design of clinical studies and the use of renal DWI in clinical practice.
登录
查看更多内容
影响因子：
2.5
作者：
Ichikawa, Shintaro;Motosugi, Utaroh;Araki, Tsutomu
通讯作者：
Araki, Tsutomu
影响因子：
3.1
作者：
Duzenli, Kursat;Ozturk, Mehmet;Erdem, Gulnur
通讯作者：
Erdem, Gulnur
影响因子：
8.1
作者：
Chen, Xiaoyan;Xiao, Wenxia;Tan, Yuyu
通讯作者：
Tan, Yuyu
影响因子：
2.9
作者：
Cheung, Jerry S.;Fan, Shu Juan;Wu, Ed X.
通讯作者：
Wu, Ed X.
影响因子：
2.5
作者：
Friedli, Iris;Crowe, Lindsey A.;Vallee, Jean-Paul
通讯作者：
Vallee, Jean-Paul