Maternal prepregnancy weight status and associations with children's development and disabilities at kindergarten.
Maternal prepregnancy weight status and associations with children's development and disabilities at kindergarten.
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DOI：
10.1038/ijo.2013.128
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发表时间：
2013-10
影响因子：
4.9
通讯作者：
Schieve, L. A.
中科院分区：
文献类型：
--
作者：
Hinkle, S. N. o;Sharma, A. J.;Kim, S. Y.;Schieve, L. A.
肥胖在育龄妇女中普遍存在，儿童发育障碍不断增加。我们研究了母亲孕前体重指数（BMI）与身体和发育障碍之间的关联，以及儿童阅读和数学技能以及精细和粗大运动功能的客观测量。我们使用了早期儿童纵向研究出生队列 (ECLS-B；n = 5200)，这是一组 2001 年出生的儿童，一直跟踪到幼儿园。根据母亲孕前BMI（公斤/平方米）对儿童进行分类：体重不足（BMI<18.5）、正常体重（BMI 18.5-24.9）、超重（BMI 25.0-29.9）、肥胖I级（BMI 30.0-34.9）和肥胖II/III级（BMI≥35.0）。收集到幼儿园为止医生诊断的残疾的家长报告，并将其分类为学习和行为或身体。儿童的阅读和数学以及精细和粗大运动功能在幼儿园根据标准化测试进行评估。线性和修正的逻辑回归模型根据母亲社会人口变量、家庭丰富变量以及儿童的性别、年龄和入园年份进行了调整。在单独的模型中对当前儿童体重指数进行了额外调整。所有数据均经过加权，以代表 2001 年出生的儿童。与正常体重母亲的孩子相比，II/III 级肥胖母亲所生的孩子的学习或行为风险增加（风险比 1.67；95% 置信区间 1.27, 2.21）），但身体残疾的风险没有增加（风险比 0.57；95% 置信区间 0.27, 1.22）。粗大运动功能（P<0.001），但不精细运动功能（P = 0.06）与母亲BMI显着相关，但在调整当前儿童BMI后，粗大运动功能减弱（P = 0.05）。儿童的阅读成绩 (P = 0.01) 但数学成绩 (P = 0.11) 与母亲 BMI 显着相关。在这个具有全国代表性的美国队列中，严重肥胖母亲所生的孩子在幼儿园被诊断出学习和行为残疾的风险增加，但身体残疾的风险却没有增加。
Obesity is prevalent among women of reproductive age, and developmental disabilities in children continue to increase. We examined associations between mother's prepregnancy body mass index (BMI) and physical and developmental disabilities, and objective measures of reading and math skills and fine and gross motor function in children. We used the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B; n = 5200), a cohort of children born in 2001 and followed until kindergarten. Children were classified according to maternal prepregnancy BMI (in kg per m2): underweight (BMI <18.5), normal weight (BMI 18.5–24.9), overweight (BMI 25.0–29.9), obese class I (BMI 30.0–34.9) and obese class II/III (BMI ≥35.0). Parent reports of doctor-diagnosed disabilities were collected up to kindergarten and classified as learning and behavioral or physical. Children's reading and math and fine and gross motor function were assessed at kindergarten according to standardized tests. Linear and modified logistic regression models were adjusted for maternal sociodemographic variables, family enrichment variables, and children's sex, age and year of kindergarten entry. Additional adjustment for current child BMI was performed in separate models. All data are weighted to be nationally representative of the children born in 2001. Compared with children of normal-weight mothers, children born to obese class II/III mothers had an increased risk of learning or behavioral (risk ratio 1.67; 95% confidence interval 1.27, 2.21)), but not physical disabilities (risk ratio 0.57; 95% confidence interval 0.27, 1.22). Gross (P<0.001), but not fine (P = 0.06) motor function was significantly associated with maternal BMI, but gross motor function was attenuated after adjustment for current child BMI (P = 0.05). Children's reading scores (P = 0.01) but not math scores (P = 0.11) were significantly associated with maternal BMI. In this nationally representative US cohort, children born to severely obese mothers had an increased risk for diagnosed learning and behavioral but not physical disabilities by kindergarten.
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DOI：
10.1152/ajpregu.00310.2010
发表时间：
2010-09-01
影响因子：
2.8
作者：
Heerwagen, Margaret J. R.;Miller, Melissa R.;Friedman, Jacob E.
通讯作者：
Friedman, Jacob E.
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM
影响因子：
3.7
作者：
Buss C;Entringer S;Davis EP;Hobel CJ;Swanson JM;Wadhwa PD;Sandman CA
通讯作者：
Sandman CA
影响因子：
9.8
作者：
通讯作者：
--
影响因子：
1.5
作者：
Lain, Kristine Y.;Catalano, Patrick M.
通讯作者：
Catalano, Patrick M.