Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy.
Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy.
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DOI：
10.1155/2012/625434
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发表时间：
2012
影响因子：
2.8
通讯作者：
Swerdloff R
中科院分区：
文献类型：
--
作者：
Surampudi PN;Wang C;Swerdloff R
老年男性性腺功能减退症是一种以血清睾酮水平低为特征的综合征，临床症状常见于年轻男性性腺功能减退症。这些症状包括性欲下降、勃起功能障碍、活力下降、肌肉质量下降、肥胖增加、情绪低落、骨质减少和骨质疏松症。性腺功能减退症是老年男性的常见疾病，60岁以上的男性中有相当大比例的人血清睾酮水平低于年轻男性成年人的下限。有多种睾酮制剂可用于治疗性腺功能减退症。许多小型研究的数据表明，睾酮治疗对老年性腺功能减退男性有几个潜在的好处。一项由NIH支持的大型多中心双盲、安慰剂对照研究正在进行中，这项研究应该会大大增强有关治疗疗效和副作用的可用信息。虽然在许多年龄组中都有安全性数据，但仍存在与睾酮治疗相关的未解决问题。我们回顾了老年男性性腺功能减退症的诊断方法以及睾酮替代治疗的益处和风险。
Hypogonadism in older men is a syndrome characterized by low serum testosterone levels and clinical symptoms often seen in hypogonadal men of younger age. These symptoms include decreased libido, erectile dysfunction, decreased vitality, decreased muscle mass, increased adiposity, depressed mood, osteopenia, and osteoporosis. Hypogonadism is a common disorder in aging men with a significant percentage of men over 60 years of age having serum testosterone levels below the lower limits of young male adults. There are a variety of testosterone formulations available for treatment of hypogonadism. Data from many small studies indicate that testosterone therapy offers several potential benefits to older hypogonadal men. A large multicenter NIH supported double blind, placebo controlled study is ongoing, and this study should greatly enhance the information available on efficacy and side effects of treatment. While safety data is available across many age groups, there are still unresolved concerns associated with testosterone therapy. We have reviewed the diagnostic methods as well as benefits and risks of testosterone replacement therapy for hypogonadism in aging men.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
3.5
作者：
Aversa, Antonio;Bruzziches, Roberto;Spera, Giovanni
通讯作者：
Spera, Giovanni
DOI：
10.1097/med.0b013e3282fc27eb
发表时间：
2008-06-01
影响因子：
3.2
作者：
Amiaz, Revital;Seidman, Stuart N.
通讯作者：
Seidman, Stuart N.
DOI：
10.1080/00365510801999068
发表时间：
2008-01-01
影响因子：
2.1
作者：
Agledahl, Ingvild;Hansen, John-Bjarne;Svartberg, Johan
通讯作者：
Svartberg, Johan
影响因子：
4.9
作者：
Breuer, B;Trungold, S;Zumoff, B
通讯作者：
Zumoff, B