Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine.

Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine.
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DOI:
10.1093/cid/cis307
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发表时间:
2012-06
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
Peiris JS
Peiris JS
中科院分区:
其他
文献类型:
--
作者:
Cowling BJ;Fang VJ;Nishiura H;Chan KH;Ng S;Ip DK;Chiu SS;Leung GM;Peiris JS

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我们将 115 名儿童随机分为三价灭活流感疫苗 (TIV) 或安慰剂。在接下来的 9 个月中,TIV 接受者发生病毒学确诊的非流感感染的风险增加(相对风险:4.40;95% 置信区间:1.31-14.8)。为了预防流感,TIV 接受者可能缺乏针对其他呼吸道病毒的临时非特异性免疫力。
We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
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