Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization
Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization
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用于多功能、简便和原位可调表面生物功能化的两亲性共聚物
DOI：
10.1002/adma.202102489
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发表时间：
2021
影响因子：
29.4
通讯作者：
U. Freudenberg
中科院分区：
文献类型：
--
作者：
A. Ruland;Saskia Schenker;Lucas Schirmer;J. Friedrichs;Andrea Meinhardt;V. Schwartz;Nadine Kaiser;Rupert Konradi;William MacDonald;Tina Helmecke;M. Sikosana;Juliane Valtin;D. Hahn;L. Renner;C. Werner;U. Freudenberg
Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene–maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water‐soluble but strongly affine for surfaces. Fine‐tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials—which is why they are referred to as “anchor polymers” (APs)—and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives—including cytokine‐complexing glycosaminoglycans, cell‐adhesion‐mediating peptides and antimicrobials—APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo‐ and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof‐of‐concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP‐functionalized surfaces.
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DOI：
10.1021/la804077t
发表时间：
2009-05-19
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Hudalla GA;Murphy WL
通讯作者：
Murphy WL
影响因子：
41.2
作者：
Darnell, Max;Mooney, David J.
通讯作者：
Mooney, David J.
影响因子：
6.2
作者：
Guler, Mustafa O.;Hsu, Lorraine;Stupp, Samuel I.
通讯作者：
Stupp, Samuel I.
影响因子：
56.9
作者：
GRISTINA, AG
通讯作者：
GRISTINA, AG
影响因子：
3.4
作者：
Hudalla GA;Murphy WL
通讯作者：
Murphy WL