Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort.
Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort.
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DOI：
10.1176/appi.ajp.2018.17101129
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发表时间：
2018-11-01
期刊：
影响因子：
--
通讯作者：
Sourander A
中科院分区：
文献类型：
--
作者：
Brown AS;Cheslack-Postava K;Rantakokko P;Kiviranta H;Hinkka-Yli-Salomäki S;McKeague IW;Surcel HM;Sourander A
自闭症是一种复杂的神经发育障碍，其病因在很大程度上尚不清楚。迄今为止，很少有研究使用母体暴露生物标志物调查产前毒素暴露和疾病风险。持久性有机污染物（Persistent Organic Pollutants，POP）是一种亲脂性卤代有机化合物，包括杀虫剂二氯二苯三氯乙烷（DDT）及其代谢产物p，p '-二氯二苯二氯乙烯（p，p'-DDE）和多氯联苯（PCBs）。我们测试了母体持久性有机污染物水平的升高是否与后代的自闭症有关。这项调查是在芬兰自闭症产前研究（FiPS-A）中进行的，这是一项基于巢式病例对照设计的全国出生队列研究。1987年至2005年出生的儿童孤独症病例通过国家登记联系得到确认。对儿童孤独症病例和配对对照（778对配对病例对照）的孕妇血清标本进行p，p '-DDE和总PCBs检测。母亲p，p '-DDE水平在第75百分位数最高时，后代患自闭症的几率显著增加，调整了母亲的年龄、产次和精神病史（OR=1.32，95%CI =1.02-1.71，p=0.03）。当母体p，p '-DDE水平高于该阈值时，自闭症伴智力残疾的几率增加两倍以上（OR=2.21，95% CI=1.32-3.69，p=0.002）。母亲的总多氯联苯和自闭症之间没有关联。这些发现提供了迄今为止第一个基于生物标志物的证据，证明母亲接触杀虫剂与后代自闭症有关。
Autism is a complex neurodevelopmental disorder with a largely unknown etiology. To date, few studies have investigated exposure to prenatal toxins and risk of the disorder using maternal biomarkers of exposure. Persistent organic pollutants (POPs) are lipophilic halogenated organic compounds including the insecticide dichlorodiphenyl trichloroethane (DDT), its metabolite p,p’-dichlorodiphenyl dichloroethylene (p,p’-DDE) and polychlorinated biphenyls (PCBs). We tested whether elevated levels of maternal POPs are associated with autism among offspring. The investigation was conducted in the Finnish Prenatal Study of Autism (FiPS-A), a national birth cohort study based on a nested case-control design. Cases of childhood autism born from 1987 to 2005 were ascertained by national registry linkages. Maternal serum specimens from early pregnancy were assayed for p,p’-DDE and total PCBs in pregnancies of cases of childhood autism and matched controls (778 matched case-control pairs). The odds of autism among offspring were significantly increased for maternal p,p’-DDE levels in the highest 75th percentile, adjusting for maternal age, parity, and psychiatric history (OR=1.32, 95% CI=1.02–1.71, p=0.03). The odds of autism with intellectual disability were increased by greater than twofold for maternal p,p'-DDE levels above this threshold (OR=2.21, 95% CI=1.32–3.69, p=0.002). There was no association between maternal total PCBs and autism. These findings provide the first biomarker-based evidence to date that maternal exposure to an insecticide is associated with autism among offspring.
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影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
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Sunyer J
DOI：
10.1016/j.ijdevneu.2016.07.001
发表时间：
2016-10-01
影响因子：
1.8
作者：
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8.8
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10.4
作者：
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通讯作者：
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