Splenic stromal cells from aged mice produce higher levels of IL-6 compared to young mice.
Splenic stromal cells from aged mice produce higher levels of IL-6 compared to young mice.
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DOI：
10.1155/2014/826987
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发表时间：
2014
影响因子：
4.6
通讯作者：
Hachimura S
中科院分区：
文献类型：
--
作者：
Park J;Miyakawa T;Shiokawa A;Nakajima-Adachi H;Tanokura M;Hachimura S
炎症衰老是指老年人因促炎细胞因子和介质（如 IL-6）分泌增加而导致的慢性炎症状态。我们的主要目标是在小鼠模型中确定与 IL-6 分泌有关的衰老影响的细胞类型。我们比较了年轻和老年小鼠脾细胞中 IL-6 的产生，并从脾中分离了几种类型的细胞，并研究了 IL-6 mRNA 表达和蛋白质产生。在 LPS 刺激下，与年轻小鼠相比，老年小鼠脾脏培养的基质细胞中 IL-6 蛋白的产量明显较高。与年轻小鼠相比，来自老年小鼠的新鲜分离的基质细胞的 IL-6 mRNA 表达水平较高。此外，体内注射LPS后，老年小鼠的基质细胞高表达IL-6 mRNA。这些结果表明，基质细胞在老年小鼠产生 IL-6 方面发挥着重要作用，并暗示它们与老年人的慢性炎症有关。
Inflamm-aging indicates the chronic inflammatory state resulting from increased secretion of proinflammatory cytokines and mediators such as IL-6 in the elderly. Our principle objective was to identify cell types that were affected with aging concerning IL-6 secretion in the murine model. We compared IL-6 production in spleen cells from both young and aged mice and isolated several types of cells from spleen and investigated IL-6 mRNA expression and protein production. IL-6 protein productions in cultured stromal cells from aged mice spleen were significantly high compared to young mice upon LPS stimulation. IL-6 mRNA expression level of freshly isolated stromal cells from aged mice was high compared to young mice. Furthermore, stromal cells of aged mice highly expressed IL-6 mRNA after LPS injection in vivo. These results suggest that stromal cells play a role in producing IL-6 in aged mice and imply that they contribute to the chronic inflammatory condition in the elderly.
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DOI：
10.1073/pnas.1531903100
发表时间：
2003-07-22
影响因子：
11.1
作者：
Kiecolt-Glaser, JK;Preacher, KJ;Glaser, R
通讯作者：
Glaser, R
影响因子：
2.4
作者：
Latifi, SQ;O'Riordan, MA;Stallion, A
通讯作者：
Stallion, A
影响因子：
5.3
作者：
Mammucari, Cristina;Rizzuto, Rosario
通讯作者：
Rizzuto, Rosario
影响因子：
7.3
作者：
den Haan JM;Mebius RE;Kraal G
通讯作者：
Kraal G
影响因子：
7.3
作者：
Komatsu N;Takayanagi H
通讯作者：
Takayanagi H