SARS-CoV-2-Indigenous Microbiota Nexus: Does Gut Microbiota Contribute to Inflammation and Disease Severity in COVID-19?
SARS-CoV-2-Indigenous Microbiota Nexus: Does Gut Microbiota Contribute to Inflammation and Disease Severity in COVID-19?
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DOI：
10.3389/fcimb.2021.590874
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发表时间：
2021
影响因子：
5.7
通讯作者：
Shankar EM
中科院分区：
文献类型：
--
作者：
Chattopadhyay I;Shankar EM
肠道微生物组改变可能在决定临床COVID-19的临床结果方面发挥至关重要的作用，并伴有潜在的合并症，如T2D、心血管疾病、肥胖等。研究需要通过使用益生元、益生菌和共生菌等组合方法来操纵COVID-19肠道微生物群的特征。对SARS-CoV-2感染中肠道微生物组变化的预测可能有助于制定有效的治疗策略。通过操纵肠道微生物群的新型和有针对性的干预措施确实代表了针对COVID-19免疫发病机制和相关合并症的有希望的治疗方法。SARS-CoV-2对与肠道微生物组分析相关的宿主先天免疫反应的影响可能有助于开发关键的应用策略，但很少有人尝试，特别是在有症状和无症状的COVID-19疾病的背景下。
Gut microbiome alterations may play a paramount role in determining the clinical outcome of clinical COVID-19 with underlying comorbid conditions like T2D, cardiovascular disorders, obesity, etc. Research is warranted to manipulate the profile of gut microbiota in COVID-19 by employing combinatorial approaches such as the use of prebiotics, probiotics and symbiotics. Prediction of gut microbiome alterations in SARS-CoV-2 infection may likely permit the development of effective therapeutic strategies. Novel and targeted interventions by manipulating gut microbiota indeed represent a promising therapeutic approach against COVID-19 immunopathogenesis and associated co-morbidities. The impact of SARS-CoV-2 on host innate immune responses associated with gut microbiome profiling is likely to contribute to the development of key strategies for application and has seldom been attempted, especially in the context of symptomatic as well as asymptomatic COVID-19 disease.
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