The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review.
The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review.
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DOI：
10.1093/geroni/igac032
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发表时间：
2022
影响因子：
7
通讯作者：
Cary MP Jr
中科院分区：
文献类型：
--
作者：
Shakya S;Bajracharya R;Ledbetter L;Cary MP Jr
加强管理和预防脆弱性取决于我们对潜在的可改变的风险因素与脆弱性之间的联系的理解。然而，潜在可改变的心脏代谢危险因素与脆弱之间的关联尚不清楚。本综述的目的是评估和综合目前检测心脏代谢危险因素与脆弱之间关系的证据。对多个数据库进行了广泛的搜索，包括MEDLINE(通过PubMed)、Embase(通过Elsevier)和Web of Science(通过Clarivate)。在老年人(≥60岁)中，分别将心脏代谢危险因素和虚弱作为主要预测因素和关注结果的研究纳入其中。使用乔安娜·布里格斯研究所的批判性评估工具来评估研究的质量。Prisma(2020)指导了这一综述，研究结果是在没有荟萃分析的情况下综合得出的。这项系统评价注册在PROSPERO(CRD42021252565)上。12项研究符合资格标准，并被纳入审查。腹型肥胖、高血糖和多种心脏代谢危险因素共发生与老年人虚弱的可能性增加有关。关于血脂异常、血压升高和虚弱之间的联系，所有研究都不一致。了解心脏代谢危险因素与虚弱之间的联系，对于制定预防和管理虚弱的量身定做的干预措施具有翻译上的好处。需要更多的研究来验证共同出现的心脏代谢危险因素的单一和特定组合与脆弱之间的预测性和临床意义上的相关性。
Enhanced management and prevention of frailty depend on our understanding of the association between potentially modifiable risk factors and frailty. However, the associations between potentially modifiable cardiometabolic risk factors and frailty are not clear. The purpose of this review was to appraise and synthesize the current evidence examining the associations between the cardiometabolic risk factors and frailty. Multiple databases, including MEDLINE (via PubMed), Embase (via Elsevier), and Web of Science (via Clarivate), were searched extensively. Studies that examined cardiometabolic risk factors and frailty as main predictors and outcome of interest, respectively, among older adults (≥60 years) were included. The Joanna Briggs Institute critical appraisal tools were used to evaluate the quality of studies. PRISMA (2020) guided this review, and findings were synthesized without meta-analysis. This systematic review was registered in PROSPERO (CRD42021252565). Twelve studies met the eligibility criteria and were included in the review. Abdominal obesity, hyperglycemia, and multiple co-occurring cardiometabolic risk factors were associated with the increased likelihood of frailty in older adults. There was inconsistency across the studies regarding the associations between dyslipidemia, elevated blood pressure, and frailty. Understanding the association between cardiometabolic risk factors and frailty can have translational benefits in developing tailored interventions for the prevention and management of frailty. More studies are needed to validate predictive and clinically significant associations between single and specific combinations of co-occurring cardiometabolic risk factors and frailty.
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影响因子：
16.2
作者：
Aguayo, Gloria A.;Hulman, Adam;Witte, Daniel R.
通讯作者：
Witte, Daniel R.
影响因子：
--
作者：
Gale, Catharine R.;Baylis, Daniel;Cooper, Cyrus;Sayer, Avan Aihie
通讯作者：
Sayer, Avan Aihie
DOI：
10.1016/j.jamda.2015.04.008
发表时间：
2015-09-01
影响因子：
7.6
作者：
Garcia-Esquinas, Esther;Graciani, Auxiliadora;Rodriguez-Artalejo, Fernando
通讯作者：
Rodriguez-Artalejo, Fernando
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.