Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing.
Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing.
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DOI：
10.1007/s11357-013-9528-9
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Sayer, Avan Aihie
中科院分区：
文献类型：
--
作者：
Gale, Catharine R.;Baylis, Daniel;Cooper, Cyrus;Sayer, Avan Aihie
横断面研究表明，较高的炎症标志物血液浓度往往在体弱的老年人中更常见，但纵向证据表明，这些炎症标志物是脆弱的风险因素是稀疏和不一致的。我们调查了来自英国老龄化纵向研究的2146名年龄在60岁至90岁以上的男性和女性的炎症标志物C反应蛋白和纤维蛋白原的基线浓度与偶发性虚弱风险之间的前瞻性关系。C-反应蛋白和纤维蛋白原与发病虚弱风险之间的关系在性别上存在显著差异（相互作用项p <0.05）。在年龄校正的逻辑回归分析中，女性中c-反应蛋白或纤维蛋白原标准差增加与偶发虚弱的比值比（95%置信区间）分别为1.69（1.32，2.17）和1.39（1.12，1.72）。对其他潜在混杂因素的进一步调整减弱了这两个估计值。对于CRP和纤维蛋白原的SD增加，女性中发生虚弱的完全校正比值比（95%置信区间）分别为1.27（0.96，1.69和1.31（1.04，1.67）。两种炎症标志物的高浓度比单独的高浓度更能强烈地预测偶发性虚弱。在男性中，任何炎症标志物与脆弱风险之间都没有显着关联。高浓度的炎症标志物C-反应蛋白和纤维蛋白原更强有力地预测女性的脆弱性。需要进一步的研究来了解这种性别差异的机制。
Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent. We investigated the prospective relation between baseline concentrations of the inflammatory markers C-reactive protein and fibrinogen and risk of incident frailty in 2146 men and women aged 60 to over 90 years from the English Longitudinal Study of Ageing. The relationship between C-reactive protein and fibrinogen and risk of incident frailty differed significantly by sex (p for interaction terms <0.05). In age-adjusted logistic regression analyses, for a standard deviation increase in c-reactive protein or fibrinogen odds ratios (95% confidence intervals) for incident frailty in women were 1.69 (1.32, 2.17) and 1.39 (1.12, 1.72) respectively. Further adjustment for other potential confounding factors attenuated both these estimates. For an SD increase in CRP and fibrinogen the fully-adjusted odds ratio (95% confidence interval) for incident frailty in women was 1.27 (0.96, 1.69 and 1.31 (1.04, 1.67) respectively. Having a high concentration of both inflammatory markers was more strongly predictive of incident frailty than having a high concentration of either marker alone. In men, there were no significant associations between any of the inflammatory markers and risk of incident frailty. High concentrations of the inflammatory markers C-reactive protein and fibrinogen are more strongly predictive of incident frailty in women than in men. Further research is needed to understand the mechanisms underlying this sex difference.
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影响因子：
7.7
作者：
Steptoe, Andrew;Breeze, Elizabeth;Nazroo, James
通讯作者：
Nazroo, James
DOI：
10.1093/gerona/61.3.262
发表时间：
2006-03-01
影响因子：
5.1
作者：
Bandeen-Roche, K;Xue, QL;Fried, LP
通讯作者：
Fried, LP
影响因子：
8.2
作者：
Lee, C. C.;Adler, A. I.;Wareham, N. J.
通讯作者：
Wareham, N. J.
影响因子：
6.7
作者：
Syddall, Holly;Roberts, Helen C.;Sayer, Avan Aihie
通讯作者：
Sayer, Avan Aihie
影响因子：
3.2
作者：
Puts, MTE;Visser, M;Lips, P
通讯作者：
Lips, P