Relationship between brain large artery characteristics and their downstream arterioles.
Relationship between brain large artery characteristics and their downstream arterioles.
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DOI：
10.1007/s13365-017-0606-0
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发表时间：
2018-03
影响因子：
3.2
通讯作者：
Morgello S
中科院分区：
文献类型：
--
作者：
Gutierrez J;Murray J;Chon C;Morgello S
我们的目的是检验脑大动脉直径与远端下游小动脉直径相关的假设。在110例尸检样本中（69%男性，76% HIV+，平均年龄51岁），我们使用多水平模型将大动脉管腔和管腔壁比与左额叶小动脉管腔和管腔壁比进行人口统计学和血管风险因素调整。比较整个大脑的大动脉特征没有发现与额叶小动脉特征的显着关联。然而，限制与所研究的小动脉上游的大动脉的比较，证明左侧额叶小动脉管腔直径与大动脉管腔直径（B=1.82 ± 0.77，P=0.01）和大动脉腔壁比（B=0.58 ± 0.29，P=0.05）之间存在独立相关性。在分层模型中，HIV+子样本中的点估计值大于HIV-子样本中的点估计值。这些发现表明以大动脉直径为代表的较高近端血流量与以小动脉扩张为代表的较低远端阻力之间存在耦合。小动脉扩张与脑实质稳态的关系有待进一步研究。
We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-to-wall ratio adjusting for demographics and vascular risk factors. Comparing the large artery characteristics of the whole brain did not disclose significant associations with frontal lobe arteriolar characteristics. However, restricting the comparison to large arteries upstream of the studied arterioles, demonstrated an independent association between left-sided frontal lobe arteriolar luminal diameter with large artery luminal diameters (B=1.82 ± 0.77, P=0.01) and with large artery lumen-to-wall ratio (B=0.58 ± 0.29, P=0.05). In stratified models, the point estimates in the HIV+ subsample were larger than in the HIV− subsample. These finding suggest coupling between higher proximal blood flow represented by large artery diameter and lower distal resistance represented by arteriolar dilatation. The relationship between arteriolar dilatation and brain parenchyma homeostasis should be further studied.
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影响因子：
9.9
作者：
FISHER, CM
通讯作者：
FISHER, CM
影响因子：
5.1
作者：
Kumral, E;Kisabay, A;Çalli, C
通讯作者：
Çalli, C
影响因子：
6.4
作者：
Gutierrez, Jose;Menshawy, Khaled;Morgello, Susan
通讯作者：
Morgello, Susan
HCV，但不是HIV是脑小血管疾病的危险因素。
DOI：
10.1212/nxi.0000000000000027
发表时间：
2014-10
期刊：
Neurology(R) neuroimmunology & neuroinflammation
影响因子：
--
作者：
Morgello S;Murray J;Van Der Elst S;Byrd D
通讯作者：
Byrd D
DOI：
10.1097/qad.0000000000000927
发表时间：
2016-01-28
期刊：
AIDS (London, England)
影响因子：
--
作者：
Gutierrez J;Menshawy K;Gonzalez M;Goldman J;Elkind MS;Marshall R;Morgello S
通讯作者：
Morgello S