Expression profile and prognostic role of sex hormone receptors in gastric cancer.
Expression profile and prognostic role of sex hormone receptors in gastric cancer.
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性激素受体在胃癌中的表达谱及其预后作用
DOI：
10.1186/1471-2407-12-566
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发表时间：
2012-12-02
期刊：
影响因子：
3.8
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Gan L;He J;Zhang X;Zhang YJ;Yu GZ;Chen Y;Pan J;Wang JJ;Wang X
背景越来越多的人对性激素受体在胃癌中的表达和可能的作用进行了研究，但这些发现大多是有争议的。方法采用实时荧光定量聚合酶链式反应和免疫组织化学方法分别检测60例和86 6例中国人胃癌组织中雌激素受体α(ERα)、雌激素受体β(ERβ)、孕激素受体(PR)和雄激素受体(AR)的基因和蛋白表达。比较四种受体的表达谱，并用卡方检验分析其与临床病理特征的关系。结果ERα、ERβ、PR和AR在胃癌组织和正常组织中均有表达，但除ERβ优势表达外，其余4种受体的表达水平均极低。这四种受体在胃肿瘤中独立表达，与癌旁正常组织相比，其表达模式呈下降趋势。4种受体的阳性表达均与肿瘤的高分级和肠型有关，ER、α和AR的阳性表达也与肿瘤早期分期有关，预后良好。但多因素生存分析显示，ER、α和AR不是影响胃癌预后的独立因素。结论性激素受体可能部分参与了胃癌的发生发展，但其临床病理意义和预后意义有限。
BackgroundIncreasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were determined in a large Chinese cohort.MethodsThe mRNA and protein expression of estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), progesterone receptor (PR), and androgen receptor (AR) in primary gastric tumors and corresponding adjacent normal tissues from 60 and 866 Chinese gastric cancer patients was detected by real-time quantitative PCR and immunohistochemistry method, respectively. The expression profile of the four receptors was compared and their associations with clinicopathological characteristics were assessed by using Chi-square test. The prognostic value of the four receptors in gastric cancer was evaluated by using univariate and multivariate Cox regression analysis.ResultsThe presence of ERα, ERβ, PR, and AR in both gastric tumors and normal tissues was confirmed but their expression levels were extremely low except for the predominance of ERβ. The four receptors were expressed independently and showed a decreased expression pattern in gastric tumors compared to adjacent normal tissues. The positive expression of the four receptors all correlated with high tumor grade and intestinal type, and ERα and AR were also associated with early TNM stage and thereby a favorable outcome. However, ERα and AR were not independent prognostic factors for gastric cancer when multivariate survival analysis was performed.ConclusionsOur findings indicate that the sex hormone receptors may be partly involved in gastric carcinogenesis but their clinicopathological and prognostic significance in gastric cancer appears to be limited.
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影响因子：
2.5
作者：
Ryu, Woo-Sang;Kim, Jong-Han;Kim, Chong-Suk
通讯作者：
Kim, Chong-Suk
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
影响因子：
9.7
作者：
Takano, N;Iizuka, N;Oka, M
通讯作者：
Oka, M
DOI：
10.1158/1078-0432.ccr-09-0033
发表时间：
2009-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Raso MG;Behrens C;Herynk MH;Liu S;Prudkin L;Ozburn NC;Woods DM;Tang X;Mehran RJ;Moran C;Lee JJ;Wistuba II
通讯作者：
Wistuba II
DOI：
10.1093/jnci/85.3.200
发表时间：
1993-02-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
ALLRED, DC;CLARK, GM;MCGUIRE, WL
通讯作者：
MCGUIRE, WL