Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila
Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila
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果蝇中的甜味神经元通过向表达 TMC 的机械敏感神经元发出信号来抑制纹理辨别
DOI：
10.7554/elife.46165
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发表时间：
2019-06
期刊：
影响因子：
7.7
通讯作者：
Yang Chung-Hui
中科院分区：
文献类型：
--
作者：
Wu Shun-Fan;Ja Ya-Long;Zhang Yi-Jie;Yang Chung-Hui
在决策过程中，不同形式刺激的整合是一个重要但尚未完全理解的过程。在这里，我们展示了果蝇在决定产卵地点时能够整合机械感觉和化学感觉的选择信息。具体来说，当两种选择都不含糖时，雌性会从更喜欢较软的选择来产卵，而当两种选择都含有糖时，雌性则会对两者漠不关心。这种蔗糖诱导的不同硬度选择之间的差异需要功能性甜味神经元，奇怪的是，也需要表达跨膜通道样（TMC）的机械敏感神经元，这种神经元在进食过程中促进了对底物硬度的区分。此外，甜味神经元的轴突直接接触大脑中表达tmc的神经元的轴突，刺激甜味神经元增加Ca2+流入表达tmc的神经元的轴突。这些结果揭示了果蝇在决定产卵地点时整合味觉和触觉信息的一种机制，并揭示了在两种不同的决定中，表达tmc的神经元在硬度区分中起相反的作用。
Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca2+ influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions.
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影响因子：
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