Growth from Birth Through Six Months for Infants of Mothers in the "Women First" Preconception Maternal Nutrition Trial.
Growth from Birth Through Six Months for Infants of Mothers in the "Women First" Preconception Maternal Nutrition Trial.
复制标题
在“妇女首先”孕妇营养试验中，母亲的婴儿从出生到六个月的生长。
DOI：
10.1016/j.jpeds.2020.09.032
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Women First Preconception Maternal Nutrition Study Group
中科院分区：
文献类型：
--
作者：
Krebs NF;Hambidge KM;Westcott JL;Garcés AL;Figueroa L;Tsefu AK;Lokangaka AL;Goudar SS;Dhaded SM;Saleem S;Ali SA;Bose CL;Derman RJ;Goldenberg RL;Thorsten VR;Sridhar A;Chowdhury D;Das A;Women First Preconception Maternal Nutrition Study Group
探讨母体营养补充剂对胎儿的线性生长效应能否维持到出生后6个月。女性优先试验是一项多国家、个人随机的临床试验，比较了孕妇营养补充开始的早孕(AR1)与怀孕~11周时(AR2)和不补充(ARM 3)的影响；干预在分娩时停止。审判地点是刚果民主共和国、危地马拉、印度和巴基斯坦。分析包括2408名随机妇女所生的2421名婴儿。主要结果是基于出生时、1个月、3个月和6个月的评估，按手臂计算的年龄长度z评分(LAZ)的轨迹。我们使用广义估计方程拟合了从出生到6个月的生长的纵向模型；母体干预效果被评估，调整了地点和基线母体协变量。在4个国家中的3个国家中，第1和第2号武器的线性增长在统计学上大于第3号武器，LAZ的平均成对平均差异分别为0.25(95%可信区间0.15-0.35；P<；.001)和0.19(95%CI 0.09-0.28；P<；.001)。与ARM 3相比，ARM 1和ARM 2发生发育迟缓的平均总体调整后相对风险(95%CI)更低：分别为0.76(0.66-0.87；P<；.001)和0.77(0.67-0.88；P<；.001)。观察到两个干预组婴儿早期的线性生长改善，支持了怀孕前和怀孕早期孕妇营养的关键重要性。临床试验网站：NCT01883193。
To evaluate whether the fetal linear growth effects of maternal nutrition supplementation would be maintained through 6 months postnatal age. The Women First trial was a multicountry, individually randomized clinical trial that compared the impact of maternal nutrition supplementation-initiated preconception (Arm 1) vs at ~11 weeks of gestation (Arm 2), vs no supplement (Arm 3); the intervention was discontinued at delivery. Trial sites were Democratic Republic of Congo, Guatemala, India, and Pakistan. Analysis includes 2421 infants born to 2408 randomized women. Primary outcome was the trajectory of length-for-age z scores (LAZ) by arm, based on assessments at birth and 1, 3, and 6 months. We fitted longitudinal models on growth from birth to 6 months using generalized estimating equations; maternal intervention effects were evaluated, adjusting for site and baseline maternal covariates. Linear growth for Arms 1 and 2 was statistically greater than for Arm 3 in 3 of the 4 countries, with average pairwise mean differences in LAZ of 0.25 (95% CI 0.15–0.35; P < .001) and 0.19 (95% CI 0.09–0.28; P < .001), respectively. Compared with Arm 3, average overall adjusted relative risks (95% CI) for stunting (LAZ <–2) were lower for Arms 1 and 2: 0.76 (0.66–0.87; P < .001) and 0.77 (0.67–0.88; P < .001), respectively. Improved linear growth in early infancy observed for the 2 intervention arms supports the critical importance of maternal nutrition before conception and in the early phase of gestation. ClinicalTrials.gov: NCT01883193.
登录
查看更多内容
母乳喂养以及腹泻发病率和死亡率的风险。
影响因子：
4.5
作者：
Lamberti LM;Fischer Walker CL;Noiman A;Victora C;Black RE
通讯作者：
Black RE
影响因子：
3.1
作者：
Hambidge KM;Krebs NF;Westcott JE;Garces A;Goudar SS;Kodkany BS;Pasha O;Tshefu A;Bose CL;Figueroa L;Goldenberg RL;Derman RJ;Friedman JE;Frank DN;McClure EM;Stolka K;Das A;Koso-Thomas M;Sundberg S;Preconception Trial Group
通讯作者：
Preconception Trial Group
影响因子：
4.5
作者：
Hambidge KM;Krebs NF;Garcés A;Westcott JE;Figueroa L;Goudar SS;Dhaded S;Pasha O;Aziz Ali S;Tshefu A;Lokangaka A;Thorsten VR;Das A;Stolka K;McClure EM;Lander RL;Bose CL;Derman RJ;Goldenberg RL;Bauserman M
通讯作者：
Bauserman M
影响因子：
4.2
作者：
King, Janet C.
通讯作者：
King, Janet C.
影响因子：
7.1
作者：
Dewey, Kathryn G.;Mridha, Malay K.;Vosti, Stephen A.
通讯作者：
Vosti, Stephen A.