Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012.
Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012.
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DOI：
10.1371/journal.pone.0114989
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Newman LM
中科院分区：
文献类型：
--
作者：
Looker KJ;Magaret AS;Turner KM;Vickerman P;Gottlieb SL;Newman LM
单纯疱疹病毒2型（HSV-2）感染在全球范围内引起重大疾病。青少年和成人感染可能表现为疼痛的生殖器溃疡。新生儿感染具有较高的发病率和死亡率。此外，HSV-2可能对HIV感染的传播有很大贡献。HSV-2感染的全球负担最近一次估计是在2003年。在这里，我们提出了2012年新的全球估计的负担流行（现有）和事件（新）HSV-2感染的女性和男性之间的15-49岁，使用更新的方法来调整测试性能和世界卫生组织（WHO）区域的估计。我们对自2000年以来全球范围内的HSV-2流行率研究进行了文献综述。然后，我们拟合了一个模型，HSV-2的发病率恒定的年龄合并HSV-2的患病率值的年龄和性别。患病率值根据检测灵敏度和特异性进行调整。该模型估计了世卫组织每个区域按性别分列的流行率和发病率，以获得全球负担估计数。通过重新调整模型来计算不确定性界限，以反映基础患病率数据的变化。2012年，我们估计全球有4.17亿15-49岁的人（范围：2.74 - 6.78亿）感染HSV-2（全球患病率为11.3%），其中2.67亿为女性。我们还估计，在2012年，1920万（范围：1300 - 2860万）15-49岁的新感染者（占全球所有个体的0.5%）。负担最重的是非洲。然而，尽管流行率较低，但东南亚和西太平洋区域由于人口规模大，在全球总数中也占很大比例。HSV-2感染的全球负担很大，使超过4亿人面临生殖器溃疡疾病、HIV感染以及HSV-2传播给伴侣或新生儿的风险增加。这些估计强调了开发疫苗、杀微生物剂和其他新的HSV预防策略的迫切需要。
Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult infection may present as painful genital ulcers. Neonatal infection has high morbidity and mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden of HSV-2 infection was last estimated for 2003. Here we present new global estimates for 2012 of the burden of prevalent (existing) and incident (new) HSV-2 infection among females and males aged 15–49 years, using updated methodology to adjust for test performance and estimate by World Health Organization (WHO) region. We conducted a literature review of HSV-2 prevalence studies world-wide since 2000. We then fitted a model with constant HSV-2 incidence by age to pooled HSV-2 prevalence values by age and sex. Prevalence values were adjusted for test sensitivity and specificity. The model estimated prevalence and incidence by sex for each WHO region to obtain global burden estimates. Uncertainty bounds were computed by refitting the model to reflect the variation in the underlying prevalence data. In 2012, we estimate that there were 417 million people aged 15–49 years (range: 274–678 million) living with HSV-2 infection world-wide (11.3% global prevalence), of whom 267 million were women. We also estimate that in 2012, 19.2 million (range: 13.0–28.6 million) individuals aged 15–49 years were newly-infected (0.5% of all individuals globally). The highest burden was in Africa. However, despite lower prevalence, South-East Asia and Western Pacific regions also contributed large numbers to the global totals because of large population sizes. The global burden of HSV-2 infection is large, leaving over 400 million people at increased risk of genital ulcer disease, HIV acquisition, and transmission of HSV-2 to partners or neonates. These estimates highlight the critical need for development of vaccines, microbicides, and other new HSV prevention strategies.
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168.9
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Lingappa, Jairam R.;Baeten, Jared M.;Wald, Anna;Hughes, James P.;Thomas, Katherine K.;Mujugira, Andrew;Mugo, Nelly;Bukusi, Elizabeth A.;Cohen, Craig R.;Katabira, Elly;Ronald, Allan;Kiarie, James;Farquhar, Carey;Stewart, Grace John;Makhema, Joseph;Essex, Myron;Were, Edwin;Fife, Kenneth H.;de Bruyn, Guy;Gray, Glenda E.;McIntyre, James A.;Manongi, Rachel;Kapiga, Saidi;Coetzee, David;Allen, Susan;Inambao, Mubiana;Kayitenkore, Kayitesi;Karita, Etienne;Kanweka, William;Delany, Sinead;Rees, Helen;Vwalika, Bellington;Magaret, Amalia S.;Wang, Richard S.;Kidoguchi, Lora;Barnes, Linda;Ridzon, Renee;Corey, Lawrence;Celum, Connie
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Celum, Connie
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Rees, Helen
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Fleming, DT;McQuillan, GM;StLouis, ME
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StLouis, ME
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作者：
Ashley-Morrow, R;Nollkamper, J;Smith, J
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